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一名新近确诊银屑病的青少年突发伴精神病性特征的躁狂，可能与英夫利西单抗有关：一例随访两年的病例报告

POSSIBLE INFLIXIMAB-ASSOCIATED SUDDEN-ONSET MANIA WITH PSYCHOTIC FEATURES IN AN ADOLESCENT WITH NEWLY DIAGNOSED PSORIASIS: A CASE REPORT WITH TWO-YEAR FOLLOW-UP

Sunan: Hannaneh Safarzadeh

Ülke: Iran

Kurum: Shahid Beheshti University of Medical Sciences, Child and Adolescent Psychiatry

一名因银屑病开始接受英夫利西单抗治疗的青少年，在每次输注后24小时内反复出现精神病性发作，并在首次输注一周后出现伴精神病性特征的躁狂，提示这些症状与用药存在时间关联及再次暴露相关性。

本报告旨在介绍一例诊断困难的青少年躁狂病例，其症状发生于药物治疗后，并伴有心理社会及神经发育方面的易感因素。患者为一名新近确诊银屑病的17岁男性青少年，既往无精神科病史；症状始于首次英夫利西单抗输注一周后，且此前不久经历过创伤性事件。临床表现包括精力增多、易激惹、精神运动性激越、言语迫促、睡眠需求减少和食欲下降、自尊心膨胀、思维奔逸，以及言语紊乱、被害妄想和夸大妄想；发育史中存在提示孤独症谱系障碍的社交沟通困难、兴趣范围狭窄及刻板僵化表现。脑磁共振成像、毒物筛查及血清自身免疫性脑炎抗体谱检查均未提供有助于诊断的发现；鉴别诊断中排除了自身免疫性脑炎、物质所致精神病性障碍，以及原发性精神病性障碍或双相障碍。住院期间开始使用抗精神病药物和心境稳定剂，并实施了9次电休克治疗（ECT），躁狂及精神病性症状均达到缓解。在两年随访期间，患者共接受三次英夫利西单抗输注，每次输注后24小时内均出现短暂的精神病性发作，但未见持续性躁狂症状加重。作者强调，可能存在的孤独症特征或可增加情感和精神病性症状失稳的易感性，而银屑病相关炎症和／或其治疗可能促成精神状态失稳，因此应重视整合精神科、发育及自身免疫方面的评估。

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APA 7: Safarzadeh, H., Davari-Ashtiani, R., & Babajani, Y. (2026, September 23-26). Possible infliximab-associated sudden-onset mania with psychotic features in an adolescent with newly diagnosed psoriasis: a case report with two-year follow-up [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/950

Vancouver: Safarzadeh H, Davari-Ashtiani R, Babajani Y. Possible infliximab-associated sudden-onset mania with psychotic features in an adolescent with newly diagnosed psoriasis: a case report with two-year follow-up [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/950

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