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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

Cerebral cortical changes in adolescents with early-onset psychosis and their implications for the neurodevelopmental hypothesis of psychosis

Cerebral cortex alterations in adolescents with early-onset psychosis and their implications for the neurodevelopmental hypothesis of psychosis

Early-onset psychosis provides a developmental model of psychosis by allowing cortical changes to be examined close to illness onset and while maturation is ongoing.

The presentation addresses cerebral cortical changes in early-onset psychosis (EOP) and their implications for the neurodevelopmental hypothesis of psychosis. It notes that psychotic disorders reflect both developmental vulnerability and progressive illness-related effects, but that the timing and biological interpretation of cortical changes remain debated; EOP beginning in childhood or adolescence offers an opportunity to examine these changes close to illness onset and while cortical maturation is ongoing. The talk reviews recent large-scale evidence of altered cortical morphology in adolescents diagnosed with EOP, including cortical thickness, cortical volume, surface area, and local gyrification. It explains that cortical thickness is particularly sensitive to adolescent maturation and illness-related changes, whereas surface area and gyrification are thought to reflect earlier disruptions in cortical expansion and organization. Findings in adolescents with EOP are compared with cortical changes reported in adults with schizophrenia and bipolar disorder, with the aim of distinguishing features associated with a general vulnerability to psychosis from those related to early onset, diagnostic subtype, or developmental timing. The findings are placed in a broader anatomical context alongside white matter microstructure, subcortical volumes, and ongoing hippocampal subfield analyses, and EOP is framed as a developmental model of psychosis using multimodal measures of brain morphology.

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