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Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun.

Rapid cycling bipolar disorder: diagnostic and treatment challenges

Rcbd: diagnostic and therapeutic challenges

Both diagnosis and treatment pose significant challenges in rapid cycling bipolar disorder; evidence to guide clinical practice is limited, and electroconvulsive therapy, clozapine, and thyroid hormone augmentation are options considered in treatment-resistant cases.

This talk addresses rapid cycling bipolar disorder (RCBD), one of the most challenging presentations of bipolar disorder to diagnose and treat in clinical practice. Although defined as four or more mood episodes within a 12-month period, its recognition is complicated by fluctuating symptom presentations, mixed mood states, incomplete longitudinal histories, and psychiatric comorbidities that obscure diagnostic clarity. Compared with non-rapid-cycling presentations, RCBD carries a substantial functional burden, with more severe and recurrent depressive episodes, greater psychosocial impairment, and increased suicidal behavior. Diagnostic challenges discussed include distinguishing rapid cycling from treatment-emergent mood instability, recognizing mixed features and comorbidities, and accurately tracking episode frequency and polarity over time. Treatment challenges stem from the limited evidence base available to guide clinical practice, variable responses to standard mood-stabilizing treatments, and the frequent need for complex treatment regimens. The presentation reviews current evidence on mood stabilizers, atypical antipsychotics, antidepressant use, and strategies for addressing treatment resistance, alongside emerging evidence on interventions such as electroconvulsive therapy (ECT), clozapine, and thyroid hormone augmentation, as well as adjunctive nonpharmacological interventions and relapse prevention strategies. The talk highlights ongoing clinical uncertainty, the current limitations of the evidence base, and the complexities clinicians face in managing this challenging patient population.

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