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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

Regional brain age changes in the temporal lobe in first-episode psychosis: a pilot MRI study

Regional brain age alterations in the temporal lobe in first episode psychosis a pilot mri study

Brain age and volume measurements in temporal regions did not differ significantly between patients with first-episode psychosis and healthy controls; however, patients consistently showed higher mean brain age values.

The study aimed to examine changes in brain-predicted age difference (brain-PAD) in the temporal lobe in first-episode psychosis (FEP), particularly in the superior temporal region, which is associated with auditory and social cognition and early psychosis. This retrospective pilot case-control study included 20 patients with FEP and 20 age-matched healthy controls. Three-dimensional T1-weighted MRI images were processed using the vol2Brain workflow to obtain temporal volume measurements; regional estimates were derived from normative data, and brain-PAD values were calculated by subtracting chronological age from predicted brain age. The groups were compared, and correlations between the resulting values and PANSS scores were examined. No statistically significant between-group differences were found in regional brain age or volume measurements (all p>0.05); however, patients consistently showed higher mean brain age values across temporal regions. No significant correlations were found between brain age estimates and PANSS scores. The authors note that, despite the absence of significant differences, regional brain age analysis may help elucidate early neurobiological changes and that studies with larger samples are needed.

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