This page was translated automatically from Turkish. Read the original

This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

From phenotypic disease networks to genomic structural equation modeling: mapping the shared genetic architecture of depression and cardiometabolic diseases

From phenotypic disease networks to genomic sem: mapping shared genetic architecture between depression and cardiometabolic diseases

There is widespread genetic overlap between psychiatric disorders and cardiovascular diseases, and the shared genes are predominantly concentrated in coagulation pathways, pointing to a common, druggable mechanism.

The study aimed to identify shared biological mechanisms between psychiatric disorders and cardiovascular disease (CVD) and their therapeutic implications. Genome-wide association study (GWAS) summary statistics for six psychiatric disorders and seven CVDs were used to conduct cross-trait genetic analyses, multi-omic gene mapping, and druggability assessments; the findings were tested through a target trial emulation in adults with newly diagnosed nonvalvular atrial fibrillation identified in Swedish national registries. Significant genetic overlap was found in 40 of the 42 disorder pairs, and 618 pleiotropic loci were identified; these were narrowed down to 441 candidate genes through integrated multi-omic analyses. Shared genes were strongly enriched in coagulation-related pathways, including the coagulation cascade, fibrin clot formation, and anticoagulant regulation. In the target trial emulation, initiation of a direct oral anticoagulant, compared with no initiation of oral anticoagulation, was associated with a lower risk of subsequent psychiatric disorders, particularly stress- and adjustment-related disorders and psychotic disorders. The presentation also describes validation analyses conducted in deeply phenotyped Chinese cohorts and experimental studies examining the contribution of coagulation factors to neuropsychiatric and cardiovascular pathology. The convergence of genetic, epidemiological, and experimental evidence positions coagulation biology as a promising therapeutic target for preventing both psychiatric disorders and their cardiovascular complications.

All WCP 2026 summaries