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EV1220

Neural dysfunction of the dorsal striatum in rat offspring exposed to maternal immune activation

NEURAL DYSFUNCTION OF DORSAL STRIATUM IN OFFSPRING RATS WITH MATERNAL IMMUNE ACTIVATION

In a maternal immune activation model, rat offspring exhibited schizophrenia-like behavioral abnormalities, increased low-frequency oscillations in the striatum, and increased DRD2 expression, all of which were reversed by haloperidol.

The aim of the study was to investigate the neural function and dopaminergic molecular underpinnings of the striatum, a key region in schizophrenia research, in rat offspring in a maternal immune activation (MIA) model. Methods included in vivo multichannel electrophysiology, behavioral tests (open field test, elevated plus maze, Y-maze, and prepulse inhibition), cytokine measurement by ELISA, Western blotting, mRNA measurement, and immunofluorescence in a Poly I:C-induced MIA model; three groups were compared (Control + saline, Poly I:C + saline, and Poly I:C + haloperidol). ELISA showed significantly higher IL-6 and TNF-alpha levels in the Poly I:C group than in controls; significance was indicated by asterisks on the poster, with no numerical p-values provided. Behavioral testing identified anxiety-like behavior (reduced time spent in the open arms of the elevated plus maze), learning and memory impairment (Y-maze), and deficits in prepulse inhibition (sensorimotor gating) at 72, 77, and 82 dB in MIA offspring; haloperidol reversed these abnormalities. Electrophysiological recordings showed markedly increased resting-state power in the delta, theta, alpha, and beta bands in the striatum of MIA offspring, with no significant difference in the gamma band. Molecular analyses showed that MIA increased striatal DRD2 expression and DRD2 and TH mRNA levels; the DRD2 antagonist haloperidol reversed these alterations. The authors state that DRD2 is a central molecular node in this process, that the findings provide neural functional evidence for the MIA model, and that they offer a theoretical basis for interventions targeting specific oscillatory rhythms.

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