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EV1113

Selective effects of full-spectrum cannabis extract on acute pain: a clinical trial

SELECTIVE EFFECTS OF FULL-SPECTRUM CANNABIS EXTRACT ON ACUTE PAIN: CLINICAL TRIAL

Full-spectrum cannabis extract reduced only the affective unpleasantness of experimentally induced thermal pain, without altering sensory thresholds or pain tolerance.

The aim was to evaluate the effects of full-spectrum cannabis extract (FSCE; CBD:THC = 40:1) on experimentally induced thermal pain perception in healthy adults. The study used a randomized, crossover, double-blind, placebo-controlled design; 70 healthy adults (43% male, mean age 31.3 years) received 1 mL of oral FSCE and placebo in two sessions separated by a 15-day washout period. Pain was induced using a contact thermode that increased the temperature incrementally (+1 degree Celsius / 5 seconds); the primary outcomes were perception threshold, tolerance, pain intensity, and unpleasantness, while the secondary outcomes were safety and tolerability. Analyses were conducted using intention-to-treat linear mixed-effects models. A significant 15.91% reduction in pain unpleasantness was observed (p < 0.01); the 20.17% reduction in pain intensity reached only trend-level significance (p = 0.06). Time to initial perception (+3.78%; p = 0.55), temperature at initial perception (+0.24%; p = 0.75), pain tolerance time (0.51% decrease; p = 0.80), and pain tolerance temperature (0.32% decrease; p = 0.49) did not change significantly. Loss to follow-up was 5.7%, and the safety profile was comparable to that of placebo (p = 0.56). In conclusion, the analgesic effect of FSCE appears to operate through emotional regulation and reduced affective distress rather than direct sensory blockade; it is considered a promising option for clinical conditions in which the emotional dimension of pain is prominent (chronic pain, fibromyalgia, and pain with comorbid anxiety or depression).

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