# Selective effects of full-spectrum cannabis extract on acute pain: a clinical trial - URL: https://alisanburak.com/en/wcp-2026-posterler/ev1113 - Language: en - Last updated: not specified - Page title: Selective effects of full-spectrum cannabis extract on acute pain: a clinical trial | WCP 2026 Summary > Full-spectrum cannabis extract reduced only the affective unpleasantness of experimentally induced thermal pain, without altering sensory thresholds or pain to… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev1113) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. EV1113 E-PosterPsikofarmakolojiRKÇ # Selective effects of full-spectrum cannabis extract on acute pain: a clinical trial SELECTIVE EFFECTS OF FULL-SPECTRUM CANNABIS EXTRACT ON ACUTE PAIN: CLINICAL TRIAL Sunan: Flávia De Lima Osório Ülke: Brazil Kurum: Ribeirão Preto Medical School, University of São Paulo (FMRP-USP) Full-spectrum cannabis extract reduced only the affective unpleasantness of experimentally induced thermal pain, without altering sensory thresholds or pain tolerance. The aim was to evaluate the effects of full-spectrum cannabis extract (FSCE; CBD:THC = 40:1) on experimentally induced thermal pain perception in healthy adults. The study used a randomized, crossover, double-blind, placebo-controlled design; 70 healthy adults (43% male, mean age 31.3 years) received 1 mL of oral FSCE and placebo in two sessions separated by a 15-day washout period. Pain was induced using a contact thermode that increased the temperature incrementally (+1 degree Celsius / 5 seconds); the primary outcomes were perception threshold, tolerance, pain intensity, and unpleasantness, while the secondary outcomes were safety and tolerability. Analyses were conducted using intention-to-treat linear mixed-effects models. A significant 15.91% reduction in pain unpleasantness was observed (p < 0.01); the 20.17% reduction in pain intensity reached only trend-level significance (p = 0.06). Time to initial perception (+3.78%; p = 0.55), temperature at initial perception (+0.24%; p = 0.75), pain tolerance time (0.51% decrease; p = 0.80), and pain tolerance temperature (0.32% decrease; p = 0.49) did not change significantly. Loss to follow-up was 5.7%, and the safety profile was comparable to that of placebo (p = 0.56). In conclusion, the analgesic effect of FSCE appears to operate through emotional regulation and reduced affective distress rather than direct sensory blockade; it is considered a promising option for clinical conditions in which the emotional dimension of pain is prominent (chronic pain, fibromyalgia, and pain with comorbid anxiety or depression). [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/390) Bu çalışmaya nasıl atıf yapılır? APA 7: Osório, F. D. L., et al. (2026, September 23-26). Selective effects of full-spectrum cannabis extract on acute pain: clinical trial [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/390 Vancouver: Osório FDL, et al. Selective effects of full-spectrum cannabis extract on acute pain: clinical trial [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/390 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [Açığı kapatmak: erişkin DEHB ilacı başlanmadan önce EKG sevk uyumunun iyileştirilmesi, kapalı döngü klinik denetim](https://alisanburak.com/en/wcp-2026-posterler/ev0088) - [Anksiyete bozukluğu olan hastalarda psikobiyotik müdahalesi: ısıl işlem görmüş Lactobacillus paracasei PS23'ün etkilerini inceleyen çift kör randomize kontrollü çalışma](https://alisanburak.com/en/wcp-2026-posterler/ev0126) - [Otizm spektrum bozukluğunda bumetanidin tedavi edici potansiyeli: güncel kanıtlar ve gelecek yönelimleri](https://alisanburak.com/en/wcp-2026-posterler/ev0157) - [Verbaskozid ile otizm spektrum bozukluğu tedavisinin mekanizmaları: ağ farmakolojisi, moleküler yerleştirme ve moleküler dinamik temelli inceleme](https://alisanburak.com/en/wcp-2026-posterler/ev0172) - [Otizm spektrum bozukluğunun çekirdek belirtilerinin tedavisinde kannabidiol: sistematik derleme](https://alisanburak.com/en/wcp-2026-posterler/ev0186) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/ev1113 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim