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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV0913

Endocannabinoid modulation of neuroinflammation-associated cognitive impairment in rodent models

ENDOCANNABINOID MODULATION OF NEUROINFLAMMATION-RELATED COGNITIVE IMPAIRMENT IN RODENT MODELS

Lipopolysaccharide-induced neuroinflammation in male rats impaired working memory at long-term assessment, while the FAAH inhibitor URB-597 produced partial rather than complete behavioral recovery.

The poster examines endocannabinoid modulation in a rodent model using the fatty acid amide hydrolase (FAAH) inhibitor URB-597. Its aims are to determine whether FAAH inhibition alters the behavioral consequences of lipopolysaccharide (LPS)-induced neuroinflammation, assess its effects on recognition memory, working memory, and task engagement, and validate automated behavioral phenotyping against human scoring. Male Sprague-Dawley rats were divided into four groups: control (saline solution), URB-597, LPS, and LPS combined with URB-597; the administered dose was reported as 0.9 mg/kg. The experimental schedule consisted of habituation, baseline behavioral testing, short-term treatment and associated behavioral testing, and long-term treatment and associated behavioral testing. Assessments used the Novel Object Recognition (NOR) test and the T-maze. In the short-term assessment, the NOR discrimination index provided no evidence of novelty preference across groups (pooled n = 25). In the long-term T-maze assessment, spontaneous alternation decreased in LPS-treated animals, while the group receiving LPS combined with URB-597 showed partial recovery toward control performance. In the rescue comparison, the alternation rate was 44% in the LPS group, 81% in the control group, and an intermediate 51% in the LPS combined with URB-597 group. Overall, LPS administration was associated with impaired working memory at long-term assessment and changes in locomotor behavior. Adding URB-597 produced partial behavioral recovery, particularly in spatial working memory at long-term assessment, suggesting a modulatory rather than fully restorative effect. The authors propose investigating sex-dependent responses and inflammatory biomarkers as the next step.

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