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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV0912

Pluronic nanoparticles as an effective delivery system for BDNF in the treatment of cognitive impairment in a mouse model of dementia

PLURONIC NANOPARTICLES AS AN EFFECTIVE DELIVERY SYSTEM FOR BDNF IN THE TREATMENT OF COGNITIVE IMPAIRMENT IN A MOUSE MODEL OF DEMENTIA

Loading BDNF into Pluronic micelles reversed scopolamine-induced memory impairment and monoaminergic deficits more effectively than pure BDNF.

The aim of the study was to compare the effects of pure brain-derived neurotrophic factor (BDNF) and BDNF-loaded micelles (BDNF-PL) on cognitive function and monoaminergic neurotransmission in a scopolamine (Sco)-induced mouse model of dementia. BDNF (40 µg/kg, intranasal) was loaded into Pluronic copolymers; dementia was induced in male ICR mice (18–20 g) by intraperitoneal scopolamine (1 mg/kg) administered for 14 days; the groups were designated as control, Sco, Sco + BDNF, and Sco + BDNF-PL. Short-term memory was assessed using the passive avoidance test, and monoamine levels in the cortex and hippocampus were measured biochemically. Scopolamine significantly impaired short-term memory (step-through latency, STL: 77±17.9 s). BDNF-PL administration increased STL more effectively (161±13.4 s) than the pure factor (140±25.9 s), bringing it close to the control level (160±13.8 s). Scopolamine caused a marked reduction in monoamine levels, while BDNF-PL not only reversed this deficit but also exerted a stimulatory effect; the most pronounced change was observed in hippocampal noradrenaline, with a more than threefold increase compared with the scopolamine-only group (1.23±0.04 ng/ml versus 0.28±0.024 ng/ml). The authors conclude that loading BDNF into Pluronic micelles significantly enhances its neuroprotective and cognition-enhancing potential.

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