# Pluronic nanoparticles as an effective delivery system for BDNF in the treatment of cognitive impairment in a mouse model of dementia - URL: https://alisanburak.com/en/wcp-2026-posterler/ev0912 - Language: en - Last updated: not specified - Page title: Pluronic nanoparticles as an effective delivery system for BDNF in the treatment of cognitive impairment in a mouse model of dementia | WCP 2026 Summary > Loading BDNF into Pluronic micelles reversed scopolamine-induced memory impairment and monoaminergic deficits more effectively than pure BDNF. This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev0912) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. EV0912 E-PosterPsychopharmacologyExperimental animal study # Pluronic nanoparticles as an effective delivery system for BDNF in the treatment of cognitive impairment in a mouse model of dementia PLURONIC NANOPARTICLES AS AN EFFECTIVE DELIVERY SYSTEM FOR BDNF IN THE TREATMENT OF COGNITIVE IMPAIRMENT IN A MOUSE MODEL OF DEMENTIA Presenter: Maria Lazarova Country: Bulgaria Loading BDNF into Pluronic micelles reversed scopolamine-induced memory impairment and monoaminergic deficits more effectively than pure BDNF. The aim of the study was to compare the effects of pure brain-derived neurotrophic factor (BDNF) and BDNF-loaded micelles (BDNF-PL) on cognitive function and monoaminergic neurotransmission in a scopolamine (Sco)-induced mouse model of dementia. BDNF (40 µg/kg, intranasal) was loaded into Pluronic copolymers; dementia was induced in male ICR mice (18–20 g) by intraperitoneal scopolamine (1 mg/kg) administered for 14 days; the groups were designated as control, Sco, Sco + BDNF, and Sco + BDNF-PL. Short-term memory was assessed using the passive avoidance test, and monoamine levels in the cortex and hippocampus were measured biochemically. Scopolamine significantly impaired short-term memory (step-through latency, STL: 77±17.9 s). BDNF-PL administration increased STL more effectively (161±13.4 s) than the pure factor (140±25.9 s), bringing it close to the control level (160±13.8 s). Scopolamine caused a marked reduction in monoamine levels, while BDNF-PL not only reversed this deficit but also exerted a stimulatory effect; the most pronounced change was observed in hippocampal noradrenaline, with a more than threefold increase compared with the scopolamine-only group (1.23±0.04 ng/ml versus 0.28±0.024 ng/ml). The authors conclude that loading BDNF into Pluronic micelles significantly enhances its neuroprotective and cognition-enhancing potential. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/16) How to cite this study APA 7: Lazarova, M., et al. (2026, September 23-26). Pluronic nanoparticles as an effective delivery system for bdnf in the treatment of cognitive impairment in a mouse model of dementia [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/16 Vancouver: Lazarova M, et al. Pluronic nanoparticles as an effective delivery system for bdnf in the treatment of cognitive impairment in a mouse model of dementia [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/16 Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [Açığı kapatmak: erişkin DEHB ilacı başlanmadan önce EKG sevk uyumunun iyileştirilmesi, kapalı döngü klinik denetim](https://alisanburak.com/en/wcp-2026-posterler/ev0088) - [Anksiyete bozukluğu olan hastalarda psikobiyotik müdahalesi: ısıl işlem görmüş Lactobacillus paracasei PS23'ün etkilerini inceleyen çift kör randomize kontrollü çalışma](https://alisanburak.com/en/wcp-2026-posterler/ev0126) - [Otizm spektrum bozukluğunda bumetanidin tedavi edici potansiyeli: güncel kanıtlar ve gelecek yönelimleri](https://alisanburak.com/en/wcp-2026-posterler/ev0157) - [Verbaskozid ile otizm spektrum bozukluğu tedavisinin mekanizmaları: ağ farmakolojisi, moleküler yerleştirme ve moleküler dinamik temelli inceleme](https://alisanburak.com/en/wcp-2026-posterler/ev0172) - [Otizm spektrum bozukluğunun çekirdek belirtilerinin tedavisinde kannabidiol: sistematik derleme](https://alisanburak.com/en/wcp-2026-posterler/ev0186) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/ev0912 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim