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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV0907

Neuroimaging findings in stimulant-induced psychosis: a review of functional MRI studies

NEUROIMAGING CORRELATES OF STIMULANT-INDUCED PSYCHOSIS: A REVIEW OF FUNCTIONAL MRI FINDINGS

Widespread cortical and subcortical dysfunction has been reported in stimulant-induced psychosis, with partial overlap with schizophrenia as well as regional differences; however, the evidence base is limited.

The study aimed to synthesize neuroimaging evidence on the neurobiology of stimulant-induced psychosis (SIP). PubMed, Embase, and Scopus were searched from inception to February 2026, and 8 studies were included in accordance with PRISMA guidelines, covering a total of 137 participants with SIP and 300 comparison participants. The primary imaging modality was resting-state fMRI in 5 studies, task-based fMRI in 2 studies, and ASL/FDG-PET in 1 study; some studies also reported regional cerebral blood flow (rCBF) or structural MRI measurements. All included studies concerned methamphetamine. Comparisons with healthy controls (including nonpsychotic methamphetamine users) revealed reduced connectivity in sensory/somatomotor, attention, salience, auditory, and temporal networks, and increased connectivity between the default mode and frontoparietal networks; reduced rCBF in the precuneus, hippocampus, insula, and frontotemporal regions; reduced metabolism in the insula/anterior cingulate cortex; and increased perfusion in the putamen and striatum. Task-based studies identified increased reaction time variability and prefrontal activation, along with alterations in reward/value processing in the nucleus accumbens, ventromedial prefrontal cortex, and posterior cingulate cortex. Findings partially overlapped with those in schizophrenia, with similar regional homogeneity (ReHo) and cortical alterations that generally appeared milder in SIP; rCBF in the precuneus and premotor cortex was higher in SIP, and cortical function was relatively preserved. The authors emphasize that regional differences may indicate partially distinct mechanisms, but that study designs, sample characteristics, and fMRI methods were heterogeneous and the evidence remains limited.

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