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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV0758

Value for money in perinatal mental health: a systematic review of the cost-effectiveness of anxiety and depression interventions

VALUE FOR MONEY IN PERINATAL MENTAL HEALTH: A SYSTEMATIC REVIEW OF THE COST-EFFECTIVENESS OF ANXIETY AND DEPRESSION INTERVENTIONS

Most interventions for perinatal anxiety and depression were found to be cost-effective, with the strongest evidence supporting cognitive behavioral therapy, interpersonal therapy, and nurse- or midwife-led interventions.

The aim is to identify and synthesize global evidence on the cost-effectiveness of interventions to prevent and treat perinatal anxiety and depression (PAD) and to assess the quality of existing studies. This systematic review, conducted in accordance with PRISMA guidelines and with its protocol registered on OSF, searched EconLit, PsycInfo, PubMed, and Web of Science for the period from January 1, 2000, to June 11, 2025; two independent researchers screened records using Rayyan and extracted data, disagreements were resolved with a third researcher, and quality was assessed using the Drummond (methodology) and CHEERS (reporting) checklists. Of the 1,093 records identified, 27 articles were included in the review: 18 trial-based economic evaluations, 8 model-based economic evaluations, and 1 cohort study; 17 included cost-utility analysis (CUA), and 13 included cost-effectiveness analysis (CEA). Seventeen studies addressed postpartum depression, and only 1 addressed perinatal anxiety; 18 used quality-adjusted life years (QALYs) as an outcome, and 5 used recovery from depression; measurement instruments included the EQ-5D-3L (n = 11), SF-6D (n = 6), and mapped EPDS (n = 6). Sixteen studies focused on treatment and 10 on prevention; usual care was the comparator in 27 studies, and 18 adopted a healthcare payer perspective. Interventions included cognitive behavioral therapy (n = 13), counseling or psychoeducation (n = 3), antidepressants (n = 2), community-based nursing care (n = 2), and other interventions such as interpersonal therapy and telemedicine (n = 6). Eighteen interventions were classified as cost-effective, 7 as uncertain, and 2 as not cost-effective; methodological quality was high (24 of the 27 studies scored above 0.8 on the Drummond criteria, but only 8 met all criteria), whereas reporting quality remained poor (only 3 studies met all CHEERS criteria). The poster reports prevalence estimates of 29% for antenatal depression, 31% for perinatal anxiety and depression, and 26% for postpartum depression. Most of the evidence comes from high-income countries; evidence gaps persist in low- and middle-income countries, particularly regarding perinatal anxiety and long-term maternal and child outcomes.

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