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Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun.

EV0420

The Youth-GEMs project: Gene–environment interactions in youth mental health trajectories across Europe

THE YOUTH-GEMS PROJECT; GENE ENVIRONMENT INTERACTIONS IN MENTAL HEALTH TRAJECTORIES OF YOUTH ACROSS EUROPE

Youth-GEMs is a multicentre European consortium project that investigates the gene–environment interactions shaping youth mental health trajectories by combining developmental (epi)genomics, exposome assessment and AI-based modelling, with the aim of identifying predictive markers.

The poster introduces the Youth-GEMs consortium, motivated by the limited understanding of the mechanisms determining youth mental health trajectories despite the fact that most mental disorders emerge before the age of 24. The project (Gene Environment interactions in Mental health trajectorieS of Youth), supported by a European Union Horizon Staying Healthy 2021 grant (Grant Agreement 101057182), adopts an integrated developmental framework to examine how genetic, epigenetic and environmental factors influence risk and resilience throughout adolescence and young adulthood. Its methodology combines developmental (epi)genomic mapping of the human brain, genomic analyses of trans-syndromal phenotypes, exposome-wide environmental assessment and AI-based modelling; multimodal data from existing population-based cohorts are being harmonised, and the first international trans-syndromal clinical cohort of help-seeking young people (N=1,000) is being established. The study is organised into seven work packages (WP1 to WP7), covering coordination, engagement and ethics, data management, developmental genomics, data mining, data integration and prediction, and clinical innovation. Expected outputs include biologically informed polygenic and exposomic scores, cell-type-specific regulatory annotations, interpretable machine learning models, a trans-syndromal assessment battery for help-seeking young people, and predictive, actionable markers of individual mental health trajectories. Ongoing engagement with young people, clinicians and stakeholders aims to translate the findings into tools for early detection, monitoring and personalised intervention. The poster provides an overview of the project and does not yet report empirical findings; according to the authors, this work will advance understanding of the mechanisms underlying youth mental health, improve the prediction of emerging illness, and support developmentally sensitive approaches to prevention and care.

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