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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

SO449

Psychosocial factors in transition to psychosis: a systematic review and meta-analysis

PSYCHOSOCIAL FACTORS FOR PSYCHOSIS CONVERSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

Psychosocial factors associated with transition to psychosis in individuals at clinical high risk for psychosis were integrated into three interacting domains—predisposing, precipitating/perpetuating, and protective—with protective factors found to be insufficiently studied.

The study aimed to synthesize evidence on psychosocial risk and protective factors associated with transition to psychosis in individuals at clinical high risk for psychosis (CHR-P) and to develop an integrated conceptual model. A systematic search of Scopus, Web of Science, PubMed, PsycInfo, Medline, and Embase was conducted in March 2025 and repeated in December 2025; 36 articles meeting the inclusion criteria represented a total of 9,346 CHR-P individuals (mean age 22.39). The poster listed predisposing factors as adverse childhood experiences (HR = 1.003; OR = 1.601), sociocultural background (HR = 1.499), substance use (HR = 1.276), baseline mental health (OR = 1.188), and negative symptoms (HR = 1.021; OR = 1.064). Precipitating/perpetuating factors were life stress (HR = 1.689) and positive symptoms (HR = 1.411; OR = 1.258); protective factors were improvement in functioning (HR = 1.009) and cognitive processes (OR = 0.613). However, the number of studies for each protective factor was insufficient (k = 2). The authors note that the literature in this field remains fragmented and limited to a risk-focused list of factors, failing to reflect the complex and culturally embedded nature of the condition. They therefore propose a conceptual model integrating these variables into three interacting domains, suggesting that the model could guide clinical assessment and intervention by incorporating interactions between risk and protective factors and stage-specific characteristics. Note: substance use was placed in the predisposing domain in the poster but listed in the precipitating/perpetuating domain in the conference abstract; the poster has been used as the basis here.

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