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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

Precision transcranial magnetic stimulation (TMS) for substance use disorders

Precision transcranial magnetic stimulation (tms) in substance use disorders

Accelerated intermittent theta burst stimulation applied to the left dorsolateral prefrontal cortex reduced methamphetamine craving compared with sham stimulation in methamphetamine use disorder in remission (t = -3.44, p = 0.01).

Although methamphetamine use disorder (MUD) is a growing cause of overdose deaths, there is no FDA-approved pharmacotherapy; the association of craving and cue reactivity with dysregulated frontostriatal and frontolimbic circuits makes transcranial magnetic stimulation (TMS) a potential therapeutic approach. The study aimed to examine the effects of accelerated theta burst stimulation (TBS), delivered in multiple sessions per day, on craving and cue reactivity in individuals with MUD in remission. In a randomized, sham-controlled, within-participant crossover design, 10 adults living with HIV who met DSM-5 criteria for MUD in remission completed three conditions: intermittent TBS (iTBS) to the left dorsolateral prefrontal cortex (L.dlPFC), continuous TBS (cTBS) to the frontopolar cortex, and sham TBS; stimulation was delivered at 1800 pulses per session, with two sessions 50 minutes apart, at 90% of the motor threshold, and craving and cue reactivity were assessed before and after stimulation using functional MRI. Participants had a mean age of 44.20 years (SD = 13.23); 8 were cisgender men and 2 were transgender women. iTBS reduced methamphetamine craving compared with sham stimulation (t = -3.44, p = 0.01), while the comparison between cTBS and sham stimulation showed a trend-level effect (t = -1.98, p = 0.08); iTBS increased activity in the L.dlPFC, whereas cTBS decreased activity in the frontopolar cortex. In conclusion, iTBS delivered to the L.dlPFC using a figure-of-eight coil is reported to be a potential treatment option for MUD.

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