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Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun.

Clinical testing of a novel colorimetric device for point-of-care measurement of capillary serum lithium in patients with bipolar disorder

Clinical testing of a novel colorimetric device for point-of-care capillary serum lithium measurement in bipolar patients

A microfluidic colorimetric device that provides results from finger-prick blood within 15 minutes showed high agreement with the reference method over the range of 0.5 to 1.1 mmol/L.

The aim was to evaluate a colorimetric, microfluidic cartridge-based point-of-care (POC) device that provides on-demand lithium measurements from finger-prick blood within 15 minutes. Lithium remains a first-line treatment for bipolar disorder but requires close monitoring because of its narrow therapeutic range (0.5 to 1.2 mmol/L). The rationale was that current monitoring guidelines leave gaps in surveillance during which lithium levels may fluctuate, increasing the risk of ineffective treatment, hospitalization, and suicide; it was hypothesized that such a system would enable patient self-monitoring, similar to personalized medicine models for chronic conditions such as diabetes, and facilitate lithium treatment in rural areas with limited testing infrastructure. The system was validated using 78 capillary blood samples collected from 16 participants over nine weeks, supplemented by 95 spiked whole-blood samples; results were compared with the reference method, atomic absorption spectroscopy (AAS), and patient acceptance of home monitoring was assessed using a questionnaire. The device showed high agreement with AAS for patient samples over the range of 0.5 to 1.1 mmol/L and successfully detected subtherapeutic concentrations in a clinical sample. Of the patients surveyed, 73% (n=22) reported a high level of interest in self-testing. The authors state that this microfluidic cartridge-based platform is a viable technology for on-demand lithium monitoring and has the potential to improve the accessibility and safety of lithium treatment.

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