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Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun.

Targeting prefrontal dysfunction in adult ADHD: a multicenter randomized controlled trial of transcranial direct current stimulation (STIM-ADHD)

Targeting prefrontal dysfunction in adult adhd: a multicenter randomized controlled trial of transcranial direct current stimulation (stim-adhd)

Data collection has been completed for a multicenter randomized controlled trial involving 250 participants testing the efficacy of multisession anodal tDCS applied to the right dorsolateral prefrontal cortex in adult ADHD; analyses are ongoing.

The study aims to evaluate the efficacy of multisession anodal transcranial direct current stimulation (tDCS) applied to the right dorsolateral prefrontal cortex (DLPFC) as an adjunctive or alternative treatment for adult attention-deficit/hyperactivity disorder (ADHD), citing the lack of robust evidence from large randomized trials in adults as its rationale. Stim-ADHD is a multicenter, randomized, double-blind, sham-controlled trial; 250 adults (N = 250) diagnosed with ADHD according to DSM-5 criteria were randomized in a 1:1 ratio to receive active or sham tDCS in addition to ongoing standard treatment. The intervention consisted of one session per day for five consecutive days (2 mA, 21 minutes; anode over the right DLPFC, cathode over the left DLPFC). The primary outcome is the change in ADHD symptoms 14 days after the intervention (CAARS DSM-IV total score); secondary outcomes include clinical and functional measures, with the durability of the effect assessed at follow-ups extending to 90 days. Data collection has been completed, and analyses are ongoing; active tDCS is hypothesized to produce a greater reduction in symptoms than sham stimulation, with the effect persisting beyond the stimulation period. As one of the first large multicenter randomized controlled trials of tDCS in adult ADHD, the study is expected to provide evidence to inform the implementation of noninvasive brain stimulation as a scalable treatment option within multimodal ADHD care.

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