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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

Understanding the relationship between inflammatory conditions and suicide through a polygenic risk approach

Understanding the association between inflammatory conditions and suicide using a polygenic risk approach

Inflammatory and immunological processes represent one of the potential biotypes of suicidal behavior, and this relationship is being investigated using polygenic risk scores for inflammatory/autoimmune conditions and examining the moderating effects of early-life stress and current stress.

The talk considers inflammation as a strong candidate mechanism, drawing on the view that suicidal behavior may involve several biotypes based on distinct etiological mechanisms. The rationale is that inflammatory/immunological conditions and their treatments are more frequently associated with suicidal behavior, and that this association cannot be explained solely by the presence of chronic and disabling physical illness. Understanding the relationship between inflammatory and immunological processes and suicidal behavior may provide new targets for intervention and prevention, particularly given the links between early-life stress, current stress, inflammation, and suicidal behavior. The presentation provides an overview of this relationship and reports findings from ongoing studies focusing on the association between polygenic risk scores calculated from previous genome-wide association studies (GWAS) of inflammatory and autoimmune conditions and current suicide risk. The moderating effects of early-life stress and current stress on this relationship are also addressed.

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