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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

Intergenerational transmission of mental disorders: parental mental disorders, parents’ experiences of childhood maltreatment, genetic predispositions, and genetic nurture as underlying pathways

Intergenerational transmission of mental disorders -parental mental disorders, parental exposure to childhood maltreatment and genetic liabilities and genetic nurturing as underlying pathways

The risk of psychopathology is transmitted across generations through both genetic and prenatal and postnatal environmental pathways.

The talk addresses intergenerational risk factors for psychiatric disorders and the pathways through which this transmission occurs. The findings presented combine population-wide register studies from Finland, Sweden, and Scotland, a meta-analytic evaluation of cohort studies across multiple countries, and findings specific to a Finnish cohort study. The findings highlight maternal and paternal mental disorders, maternal and paternal experiences of childhood maltreatment, maternal obesity, diabetes, and hypertensive disorders, and psychological distress during pregnancy as risk factors for mental disorders and symptoms in children; positive maternal mental health during pregnancy is identified as a potential factor promoting mental health. The meta-analytic study shows that the influence of polygenic risk scores for psychopathology on psychiatric symptoms in children is mediated by both direct and indirect genetic effects, with the indirect effects suggesting possible genetic nurture. Cross-cohort comparisons found that the effect of maternal depressive and anxiety symptoms during pregnancy on child psychopathology was independent of genetic predispositions, while also being moderated by these predispositions. No numerical effect sizes or p-values were reported in the abstract; the conclusion emphasizes that risk is transmitted across generations and that both genetic and environmental pathways contribute to this transmission.

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