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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV1254

Sistemik immün inflamasyon indeksi ile değerlendirilen şizofrenide sistemik inflamatuvar yük: kontrollü bir olgu kontrol çalışması (Systemic inflammatory burden in schizophrenia assessed using the systemic immune-inflammation index: a controlled case-control study)

SYSTEMIC INFLAMMATORY BURDEN IN SCHIZOPHRENIA ASSESSED THROUGH THE SYSTEMIC IMMUNE INFLAMMATION INDEX: A CONTROLLED CASE CONTROL STUDY

The systemic immune-inflammation index is higher in schizophrenia than in healthy controls, and this difference persists after adjustment for age and sex; however, its discriminatory ability is insufficient for diagnostic use.

The aim was to determine whether the systemic immune-inflammation index (SII) was elevated in adults with DSM-5-confirmed schizophrenia compared with psychiatrically healthy controls, and whether this association persisted after adjustment for age and sex. This controlled observational case-control study, conducted between March 2024 and January 2025, included 124 patients with schizophrenia taking atypical antipsychotics other than clozapine and 128 healthy controls screened for inflammatory and psychiatric conditions; exclusion criteria were autoimmune, chronic inflammatory, or hematological disease, recent infection, malignancy, substance use disorder, pregnancy or the postpartum period, and immunomodulatory treatment. Analyses included an independent-samples t-test, a chi-square test, ANCOVA, and ROC analysis. Mean SII was 610 ± 240 in the schizophrenia group and 520 ± 220 in controls (difference +90; t = 3.18; p = 0.002; Cohen's d = 0.39, a small-to-moderate effect size). Sex distribution differed between groups (χ² = 23.4; p<0.001), and the elevation persisted in the analysis adjusted for age and sex (F = 9.6; p = 0.002). ROC analysis showed only limited discriminatory ability, with an area under the curve (AUC) of 0.66 (95% confidence interval 0.59–0.73). The authors interpreted SII as reflecting susceptibility rather than diagnostic specificity.

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