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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV1253

Inflammatory signatures across stages of psychotic disorders: a comparative analysis of acute psychosis and schizophrenia in a retrospective inpatient cohort

INFLAMMATORY SIGNATURES ACROSS STAGES OF PSYCHOTIC DISORDERS: COMPARATIVE ANALYSIS OF ACUTE PSYCHOSIS AND SCHIZOPHRENIA IN A RETROSPECTIVE INPATIENT COHORT

NLR, PLR, MLR, and SII values are higher in acute psychosis, whereas fibrinogen is higher in schizophrenia, indicating marker-specific inflammatory profiles at different clinical stages of psychotic disorders.

The aim was to compare peripheral inflammatory markers between schizophrenia and acute and transient psychotic disorder and to evaluate age, sex, and smoking as predictors of biomarker variability. A total of 187 inpatients were examined in this retrospective cohort (schizophrenia n = 105; acute/transient psychosis n = 82). Leukocyte subtypes, platelets, C-reactive protein, erythrocyte sedimentation rate, and fibrinogen were assessed, and the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII) were calculated; parametric tests or the Mann–Whitney U test and multiple regression were used. At admission, mean (standard deviation) values for acute psychosis versus schizophrenia were as follows: NLR 2.19 (1.04) versus 1.79 (1.16), p = 0.004; PLR 135.94 (40.81) versus 120.42 (80.51), p<0.001; MLR 0.33 (0.16) versus 0.31 (0.33), p = 0.03; SII 587.12 (373.16) versus 452.14 (312.89), p = 0.004. Fibrinogen, however, was higher in schizophrenia: 298.75 (51.17) versus 269.29 (83.63), p = 0.02. Relative mean differences were reported as 22.3% for NLR, 12.9% for PLR, 6.5% for MLR, and 29.9% for SII, with higher values in acute psychosis, and 9.9% for fibrinogen, with higher values in schizophrenia. Patients with acute psychosis were younger; sex was associated with PLR and fibrinogen, while smoking was associated with erythrocyte sedimentation rate, NLR, and PLR. The authors concluded that the findings support marker-specific inflammatory profiles at different clinical stages of psychotic disorders.

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