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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV1249

Development of a screening questionnaire for cognitive decline in patients with schizophrenia: diagnostic performance and clinical utility

DEVELOPMENT OF THE SCREENING QUESTIONNAIRE OF COGNITIVE DECLINE IN PATIENTS WITH SCHIZOPHRENIA: DIAGNOSTIC PERFORMANCE AND CLINICAL UTILITY

Preliminary analyses identified learning and processing speed as the optimal combination for an ultra-brief, two-item screening questionnaire.

The aim is to report the development of an ultra-brief, two-item screening questionnaire to address the need for an easy-to-administer, reliable screening tool for cognitive decline, which affects most patients with schizophrenia and determines occupational outcomes. More than 500 patients with schizophrenia were to be recruited from centers affiliated with the COCORO (Cognitive Genetics Collaborative Research Organization) network in Japan. One potential domain was identified from eight candidate cognitive domains based on its ability to discriminate cognitive decline, and candidate item pairs (dyads) were formed by pairing one question from this domain with one question from each of the other domains. Cognitive decline was defined as the difference between current estimated intelligence quotient (estimated IQ, EIQ; WAIS-III Symbol Search and Similarities subtests) and premorbid intelligence quotient (Japanese Adult Reading Test, JART). The outcome variable was dichotomized into declined (EIQ–JART of -15 or below) and mildly declined/preserved (above -15). Current cognitive functioning was measured using the Brief Assessment of Cognition in Schizophrenia (BACS). The screening performance of the candidate dyads was evaluated using receiver operating characteristic (ROC) curve analyses, and clinical utility was assessed using positive and negative predictive values (PPV/NPV). Only preliminary findings were presented because the study had not yet been completed. Among the potential domains, learning yielded the highest area under the curve (AUC), with relatively high AUC values also found for comprehension, problem-solving, planning, and processing speed. Learning and processing speed were identified as the optimal dyad, with adequate screening performance (sensitivity above 0.7 and PPV above 0.6). Its validity was supported by a stronger correlation with actual cognitive decline (EIQ–JART) than that of the other candidate dyads. Once finalized, this ultra-brief form, which can be administered in under 1–2 minutes and requires no training or preparation, may enable time- and resource-efficient screening for cognitive impairment in general clinical settings.

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