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EV1103

Acute psychosis following rabies vaccination: a rare case report

ACUTE PSYCHOSIS FOLLOWING ANTI-RABIES VACCINATION: A RARE CASE REPORT

Acute psychosis temporally associated with rabies vaccination may occur rarely; outcomes are favorable with early recognition and treatment.

This poster presents a rare case of acute psychosis temporally associated with rabies vaccination. A 22-year-old man with no previous psychiatric history developed symptoms 1 day after his fourth vaccine dose. The clinical presentation included grandiose and persecutory delusions, hallucinations, aggression, increased religiosity, and reduced sleep. Brain MRI, EEG, and laboratory investigations were normal, with no evidence of encephalitis. He was diagnosed with acute and transient psychotic disorder (ICD-11: 6A23) and possible vaccine-associated psychosis. Treatment included olanzapine at doses up to 15 mg/day, a short course of a benzodiazepine, and supportive care. The patient showed marked improvement within 2 weeks, achieved full remission by week 4, and remained stable at the 3-month follow-up. The authors emphasize that acute psychosis following vaccination is rare and that early diagnosis and treatment lead to favorable outcomes.

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