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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV1025

Benzodiazepine exposure during pregnancy and risk of pregnancy loss: a meta-analysis

BENZODIAZEPINE EXPOSURE IN PREGNANCY AND THE RISK OF PREGNANCY LOSS: A META-ANALYSIS

Benzodiazepine use during pregnancy is associated with an approximately 1.5-fold increase in miscarriage risk, and this association applies to both short- and long-acting agents.

The study aimed to quantify the risk of miscarriage associated with the use of short- and long-acting benzodiazepines (BZDs). This systematic review and meta-analysis, registered in PROSPERO (CRD420250650157), searched PubMed, CINAHL, PsycINFO, Scopus, and Web of Science, included observational studies examining BZD use during pregnancy, and pooled the findings using a random-effects model. The search identified 1,568 records; 1,061 records were screened, 61 records were assessed at the abstract level, and 31 articles underwent full-text review, with 11 studies ultimately included. The included studies were published between 1998 and 2026; five had a case-control design, five were cohort studies, and one was cross-sectional. All were conducted in high-income countries (five in Europe, four in Asia, one in North America, and one in the Middle East). A total of 6,171,477 participants were studied, of whom 85,235 had been exposed to BZDs. The overall odds ratio (OR) was 1.52 (95% confidence interval [CI] 1.30 to 1.79), with high heterogeneity (I²=93.8%, p<0.001). In subgroup analyses, the OR was 1.47 (1.04 to 2.08) for long-acting BZDs and 1.63 (1.40 to 1.90) for short-acting BZDs. According to the authors, risks and benefits should be carefully weighed when prescribing BZDs to pregnant patients, and further research is needed to clarify the effects of exposure timing and dosage.

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