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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV1003

Quality of life after epilepsy surgery in drug-resistant epilepsy: A systematic review and meta-analysis using QOLIE scales

QUALITY OF LIFE AFTER EPILEPSY SURGERY IN DRUG RESISTANT EPILEPSY A SYSTEMATIC REVIEW AND META ANALYSIS USING QOLIE SCALES

Epilepsy surgery significantly improves overall QOLIE scores and all subdomains, with the greatest gains in seizure worry and social functioning.

The aim was to quantify postoperative changes in overall QOLIE and subscale scores in drug-resistant epilepsy, which affects approximately one-third of patients with epilepsy. MEDLINE, EMBASE, PsycINFO, and CENTRAL were systematically searched; longitudinal studies reporting preoperative and postoperative QOLIE-31 or QOLIE-89 scores were included, and a random-effects meta-analysis was performed using standardised mean differences (Hedges’ g). The primary outcome was the overall QOLIE score, and the secondary outcomes were the 7 subscales. The primary analysis pooled 12 studies and 479 patients; the SMD for the overall QOLIE score was 0.95 (95% confidence interval 0.57 to 1.34; p < 0.001; I² = 81.6%). The greatest gains across subdomains were in seizure worry (SMD 1.47; higher scores indicate less worry) and social functioning (SMD 1.19); moderate improvements were observed in overall quality of life (SMD 1.05), medication effects (SMD 0.98), cognitive functioning (SMD 0.85), emotional well-being (SMD 0.78), and energy/fatigue (SMD 0.72), all with p-values of 0.001 or less. The authors note that the findings support epilepsy surgery not only as a means of seizure control but also as a quality-of-life intervention; however, given the high heterogeneity, follow-up duration and reporting should be standardised in future studies.

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