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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV0882

Accelerated low-intensity iTBS reduces depression severity and suicide risk in major depressive disorder: a randomized controlled trial

ACCELERATED LOW-INTENSITY ITBS REDUCES DEPRESSION SEVERITY AND SUICIDAL RISK IN MAJOR DEPRESSIVE DISORDER: A RANDOMIZED CONTROLLED TRIAL

Accelerated low-intensity intermittent theta-burst stimulation administered over four days produced significant reductions in depressive symptoms and suicidal ideation compared with sham stimulation.

The study aimed to evaluate the antidepressant and antisuicidal effects of accelerated low-intensity intermittent theta-burst stimulation (Li-iTBS) in patients with major depressive disorder. In this single-blind, sham-controlled randomized controlled trial using an accelerated protocol, 173 individuals were assessed for eligibility, 125 were excluded, and 48 patients were randomized (active Li-iTBS n = 23, sham n = 25); due to incomplete treatment sessions and unavailable final assessments, 39 patients (active n = 20, sham n = 19) were included in the analysis. The intervention was delivered to the left dorsolateral prefrontal cortex in a total of 20 sessions, with 5 sessions per day over 4 consecutive days, using bursts of three pulses at 50 Hz, lasting 200 seconds per session at an intensity of 3.9 to 4.9 mT; assessments used the HDRS-17, PHQ-9, and HDRS item 3 for suicidal ideation. The reduction in HDRS-17 scores was significantly greater in the active group than in the sham group (p < 0.001). The response rate was reported as 90% (18/20) in the active group and 10.5% (2/19) in the sham group (p < 0.001); the remission rate was 40% (8/20) in the active group and 0% (0/19) in the sham group (p < 0.002). PHQ-9 scores decreased from 14.5 ± 6.5 to 5.1 ± 4.4 in the active group (n = 18) and from 19.0 ± 5.0 to 12.8 ± 6.0 in the sham group (n = 19), with a significant between-group difference (p = 0.014). Following accelerated Li-iTBS, no suicidal ideation was detected in 95% of patients (post-treatment p = 0.016). The authors state that the protocol was well tolerated and that low-intensity neuromodulation may offer an accessible treatment option for major depressive disorder.

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