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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV0583

Exercise-related neurocognitive and lipid changes in older adults at high risk for mild cognitive impairment: a pilot study

EXERCISE-RELATED NEUROCOGNITIVE AND LIPID CHANGES IN OLDER ADULTS AT HIGH RISK OF MILD COGNITIVE IMPAIRMENT: PILOT STUDY

Six months of strength training was associated with faster Go/No-Go responses, while LDL and non-HDL cholesterol followed exercise-specific trajectories.

The aim was to examine whether a 6-month structured exercise intervention was associated with domain-specific neurocognitive changes and lipid responses in older adults at high risk for mild cognitive impairment (MCI). A two-group, 24-week pilot intervention was conducted in 31 high-risk older adults: progressive strength training at 70–85% of one-repetition maximum (1RM) (n = 17) or whole-body stretching as an active control (n = 14), with supervised sessions twice weekly; assessments were performed at baseline, 3 months, and 6 months. Executive function and cognitive flexibility were assessed using the Stroop and Trail Making tests, inhibitory control using Go/No-Go, visuospatial processing using the Manikin task, and working memory using the 6-Letter Memory Search Test; LDL and non-HDL cholesterol were measured. The analysis used a repeated-measures general linear model (GLM) adjusted for age and baseline MoCA score. Three significant group x time interactions were identified over six months: Go/No-Go reaction time (p = 0.040; partial eta squared, ηp² = 0.125), LDL cholesterol (p = 0.015; ηp² = 0.145), and non-HDL cholesterol (p = 0.019; ηp² = 0.137). No significant group x time interactions were found for the other outcomes: Stroop p = 0.751, Trail Making p = 0.743, Go/No-Go accuracy p = 0.575, 6-letter memory p = 0.671, and Manikin accuracy p = 0.952. The authors concluded that strength training was associated with faster inhibitory control responses, while LDL and non-HDL cholesterol followed exercise-specific trajectories over 6 months; the finding is presented as a preliminary signal from a pilot study, concentrated in inhibitory control and atherogenic lipid markers.

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