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EV0550

Psychiatric symptoms and associated factors in a large Peruvian Huntington’s disease cohort

PSYCHIATRIC SYMPTOMS AND ASSOCIATED FACTORS IN A LARGE PERUVIAN HUNTINGTON’S DISEASE COHORT

Psychiatric symptoms were identified in 93.8% of patients in a Peruvian Huntington’s disease cohort. The most common symptoms were irritability, depression, and aggressive or violent behavior, and the presence of psychiatric symptoms was associated with lower functional capacity.

The aim of the study was to identify the main psychiatric symptoms and their associated factors in a large Peruvian Huntington’s disease cohort. A retrospective medical record review covering the period from 2016 to 2025 was conducted at a specialized outpatient clinic at Peru’s national neurology referral center (INCN). Records of 130 patients with Huntington’s disease were evaluated, and sociodemographic, clinical, and psychiatric variables were examined using descriptive statistics and hypothesis testing. Psychiatric symptoms were identified in 93.8% of patients. The most common symptoms were irritability (82.8%), depression (62.3%), aggressive or violent behavior (46.7%), apathy (38.5%), sleep disturbances (37.7%), and perseverative or obsessive behavior (34.4%). Patients with psychiatric symptoms were found to have lower functional capacity, with median values of 10 (interquartile range (IQR) 6.8 to 12.2) and 3.5 (IQR 0.25 to 6.0) reported in the comparison (p=0.003). Among the associated factors, male sex in the presence of the major allele was reported to be significantly associated with perseverative or obsessive behaviors. Trend-level associations were also observed between psychiatric symptoms and sleep disturbances and employment status. The authors emphasize that the association between psychiatric symptoms and lower functional capacity reflects the psychiatric burden of Huntington’s disease and that psychiatric assessment should be an integral part of multidisciplinary treatment.

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