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EV0371

Personality and psychosocial vulnerability in mood disorders associated with overt and subclinical hypothyroidism

PERSONALITY AND PSYCHOSOCIAL VULNERABILITY IN AFFECTIVE DISORDERS WITH OVERT AND SUBCLINICAL HYPOTHYROIDISM

Among patients with anxiety and depressive disorders, those with hypothyroidism showed higher rates of accentuated personality traits and psychosocial burden than euthyroid psychiatric patients, with this pattern most pronounced in the subclinical group.

The study aimed to compare personality traits and psychosocial stressors across overt hypothyroid, subclinical hypothyroid, and euthyroid groups to investigate the relationship between psychiatric symptoms in hypothyroidism and factors beyond hormonal status. In a cross-sectional design, 159 adults aged 20 to 60 with anxiety and/or depressive disorders were matched for age and sex and divided into three groups: overt hypothyroidism (n=41), subclinical hypothyroidism (n=68), and euthyroid psychiatric controls (n=50); the controls were psychiatric patients, not healthy individuals. Personality traits were assessed using the Schmieschek-Leonhard Personality Questionnaire, with scores above 12 considered clinically significant accentuated traits and multiple traits permitted; psychosocial stressors and a history of endocrine disease in first-degree relatives were recorded through structured history-taking, and frequencies were compared using the chi-square or Fisher’s exact test. In the overt / subclinical / euthyroid groups, respectively, anxious traits were found in 32.0% / 38.0% / 18.0% (p=0.035), dysthymic traits in 26.0% / 30.0% / 12.0% (p=0.048), and emotive traits in 28.0% / 32.0% / 14.0% (p=0.041). Regarding contextual vulnerability, the prevalence of major stressors was reported as 58% / 62% / 36% (p=0.049 for the overt group versus controls; p=0.041 for the subclinical group versus controls), and a family history of endocrine disease as 54% / 50% / 28% (p=0.038 and p=0.047 for the hypothyroid groups versus controls). The authors note that assessing personality and stress may help explain clinical heterogeneity and support the integration of psychotherapeutic and endocrine care, while emphasizing that cross-sectional comparisons do not establish causality.

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