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Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun.

EV0342

The BANOTA framework: a lifestyle psychiatry protocol for antipsychotic-induced weight gain through regulation of the gut–brain axis

THE BANOTA FRAMEWORK: A LIFESTYLE PSYCHIATRY PROTOCOL TO COUNTERACT ANTIPSYCHOTIC-INDUCED WEIGHT GAIN THROUGH GUT–BRAIN AXIS MODULATION

The 3 patients who completed the six-component BANOTA lifestyle protocol over 12 weeks achieved a mean weight loss of 5.7 kg, with no psychiatric exacerbations.

The aim is to demonstrate the clinical feasibility of BANOTA, a holistic lifestyle psychiatry protocol developed to reduce antipsychotic-induced weight gain and metabolic syndrome, particularly associated with olanzapine; the poster notes that metabolic syndrome has been reported in approximately 50% to 60% of people taking antipsychotics. The protocol consists of six pillars: balanced nutrition (a Mediterranean-style diet), physical activity at least 5 days per week, normal sleep through cognitive behavioral therapy for insomnia (CBT-I), microbiota regulation with synbiotics, treatment adherence, and mindfulness based on behavioral and cognitive skills. The design is a 12-week prospective case series (N=6); the primary outcome measure is body weight, and secondary measures are adherence, metabolic parameters, and psychiatric stability. Three patients completed the protocol (2 women, 1 man), 2 male participants withdrew voluntarily, and 1 participant discontinued due to impaired insight. Among those who completed the protocol, weight changed from 78 kg to 72 kg (-6 kg), from 68 kg to 63 kg (-5 kg), and from 74 kg to 68 kg (-6 kg), respectively, with a reported mean weight loss of 5.7 kg. In addition, no psychiatric exacerbations occurred, metabolic markers improved, and antipsychotic doses remained unchanged or were reduced. The authors consider the protocol promising but supported only by preliminary evidence, emphasizing the need for larger randomized controlled trials (RCTs) to validate it.

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