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EV0315

Clinical effectiveness of combining traditional Chinese medicine and Western medicine in patients with depression

CLINICAL EFFECTIVENESS OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE IN PATIENTS WITH DEPRESSION

Treatment combining traditional Chinese medicine and Western medicine was associated with lower depression scores and a higher response rate than standard Western pharmacotherapy alone.

The aim of the study was to evaluate the clinical effectiveness of a treatment strategy combining traditional Chinese medicine and Western medicine in patients with depression and to investigate its potential advantages. A retrospective analysis was conducted of patients treated in the Department of Clinical Psychology at Chongqing Rongchang District Hospital of Traditional Chinese Medicine between January 2024 and June 2025. Patients receiving combined treatment that included the Jieyu Shugan formula were assigned to the study group (n = 58), while those receiving only standard Western pharmacotherapy were assigned to the control group (n = 44), with a total of 102 patients evaluated. At baseline, there were no significant differences between the groups in age (45.6 +/- 12.1 years versus 46.5 +/- 12.6 years), proportion of women (58.6% [34/58] versus 56.8% [25/44]), illness duration (4 years [IQR 2 to 6] versus 5 years [IQR 2 to 8]), or HAMD-17 score (23.7 +/- 4.8 versus 24.1 +/- 5.1) (p > 0.05). After six to eight weeks of treatment, the study group had significantly lower HAMD-17 scores (10.5 +/- 5.0 versus 13.2 +/- 5.8) and a higher clinical response rate (70.7% [41/58] versus 47.7% [21/44]). The rate of improvement in depression was 58.6% (34/58) versus 38.6% (17/44), and the rate of improvement in sleep was 62.1% (36/58) versus 38.6% (17/44), with statistically significant differences (p < 0.05). The incidence of adverse effects did not differ significantly between the groups (17.2% [10/58] versus 22.7% [10/44]; p > 0.05). In conclusion, the combined traditional Chinese medicine and Western medicine approach was reported to be associated with a favorable clinical effectiveness and safety profile in patients with depression.

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