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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV0243

Prevalence of depression in adolescent girls and boys with ADHD: a systematic review and meta-analysis

PREVALENCE OF DEPRESSION AMONG ADOLESCENT GIRLS AND BOYS WITH ADHD: A SYSTEMATIC REVIEW AND META-ANALYSIS

Adolescent girls with ADHD have approximately twice the risk of comorbid depression compared with boys (RR 1.96).

The study aimed to examine sex differences in the prevalence of depression and depressive symptoms among adolescents with attention-deficit/hyperactivity disorder (ADHD), focusing specifically on adolescence; it notes that previous meta-analyses yielded mixed results because of their broad age range (3 to 18 years). The study followed the PRISMA statement, was registered with PROSPERO (CRD42024531471), and searched four databases. Risk of bias was assessed using the Joanna Briggs Institute (JBI) checklist for prevalence studies, and certainty of evidence was evaluated using the GRADE approach; two separate meta-analyses were conducted to calculate the risk ratio (RR) for a depression diagnosis and the standardized mean difference (SMD) for depressive symptom scores. A total of 5,783 records were screened, and none of the included studies had a high overall risk of bias. The first meta-analysis included five studies involving 203,523 participants aged 12 to 18 years (60% male), and the pooled prevalence of diagnosed depression was 13% (95% confidence interval [CI] 0.07 to 0.21). The overall risk ratio for girls was 1.96 (95% CI 1.56 to 2.48; p<0.001; I2=93.1%), with moderate certainty of evidence; the prediction interval was 1.05 to 3.67. The second meta-analysis included three studies involving 364 adolescents (71% of the control group were male), and the pooled SMD was 0.42 (95% CI 0.15 to 0.69; p=0.002; I2=7.4%), although the certainty of evidence was rated as very low. In conclusion, adolescent girls with ADHD have approximately twice the risk of comorbid depression compared with boys and report higher levels of depressive symptoms.

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