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EV0224

Effectiveness of exposure and response prevention therapy combined with an SSRI in adolescents with obsessive-compulsive disorder: Real-world experience from Bangladesh

EFFICACY OF EXPOSURE AND RESPONSE PREVENTION THERAPY COMBINED WITH SSRIS IN ADOLESCENTS WITH OBSESSIVE-COMPULSIVE DISORDER: A REAL LIFE EXPERIENCE FROM BANGLADESH

Adding a seven-session exposure and response prevention protocol to standard SSRI treatment for adolescent obsessive-compulsive disorder resulted in greater symptom reduction and a higher remission rate at week 12.

The aim was to evaluate the clinical effectiveness and symptom reduction achieved by adding a seven-session exposure and response prevention (ERP) protocol, delivered every two weeks, to standard SSRI treatment in adolescents with obsessive-compulsive disorder (OCD); SSRIs alone reduce symptoms by 20% to 40%, and real-world data on adding ERP in adolescents remain limited. The study used a two-arm, parallel interventional design involving 40 adolescents aged 11 to 17 years with Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) scores of 16 or higher; group A (n = 21) received seven sessions of ERP alongside an SSRI, while group B (n = 19) received SSRI monotherapy. The CY-BOCS was administered at baseline and at weeks 6 and 12, and remission was defined as a CY-BOCS score of 12 or lower. Remission rates at week 6 were 9.5% in the ERP + SSRI arm and 21.1% in the SSRI-only arm; at week 12, they were 42.9% in the ERP + SSRI arm and 28.6% in the SSRI-only arm. Rapid response at week 6 was reported in 85.7% of the combination arm versus 26.3% of the SSRI-only arm. The overall reduction in symptom severity was 43.8% in the combination arm and 28.2% with SSRI monotherapy, and the difference was statistically significant (p < 0.001). The seven-session protocol delivered every two weeks proved feasible, with a high completion rate. In conclusion, adding brief ERP to standard SSRI treatment results in greater symptom reduction and better remission outcomes in adolescent OCD.

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