This page was translated automatically from Turkish. Read the original

This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

EV0080

Pediatrik dikkat eksikliği hiperaktivite bozukluğunda metilfenidat yanıtının öngörücüsü olarak kantitatif EEG: boylamsal bir çalışma (Quantitative EEG as a predictor of methylphenidate response in pediatric attention-deficit/hyperactivity disorder: a longitudinal study)

QUANTITATIVE EEG AS A PREDICTOR OF METHYLPHENIDATE RESPONSE IN PEDIATRIC ADHD: A LONGITUDINAL STUDY

Lower baseline Oz alpha power is associated with a better clinical response to methylphenidate.

The aim of the study was to evaluate the role of baseline quantitative EEG (qEEG) absolute power measurements in predicting clinical response to methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD). This longitudinal observational study included 43 male participants aged 8 to 16 years. ADHD severity was measured using the Conners Parent Rating Scale (CPRS), and 32-channel awake resting-state EEG was recorded. Absolute power was analyzed at the Fz, Cz, Oz, and Pz electrodes. Response was assessed after 4 weeks of methylphenidate treatment, with a good response defined as a reduction of at least 25% in the total CPRS score. Between-group comparisons showed lower Fz delta power (p=0.04) and Oz alpha power (p=0.02) in good responders. Correlation analyses of clinical improvement showed associations between Fz beta power and change in hyperactivity (rho=-0.50; p=0.03), Fz alpha power and change in hyperactivity (rho=-0.48; p=0.01), Oz alpha power and changes in both hyperactivity (rho=-0.39; p=0.01) and total CPRS score (rho=-0.39; p=0.01), Oz beta power and change in total CPRS score (rho=-0.36; p=0.02), and the Fz theta/beta ratio and change in total CPRS score (rho=0.41; p=0.02). The poster's main finding was that lower baseline Oz alpha power was associated with a better response to methylphenidate. In conclusion, baseline qEEG measurements, particularly posterior alpha power, differed between good and poor responders and were associated with clinical improvement. The authors note that these findings suggest the potential of neurophysiological markers for predicting treatment response in ADHD, but require validation in studies with larger samples.

All WCP 2026 summaries