# 惊恐障碍患者接受正念认知疗法后临床症状改善的结构性精神影像组学特征：一项随机对照试验 - URL: https://alisanburak.com/zh/wcp-2026-posterler/so362 - Language: zh - Last updated: not specified - Page title: 惊恐障碍患者接受正念认知疗法后临床症状改善的结构性精神影像组学特征：一项随机对照试验 | WCP 2026 摘要 > 惊恐障碍患者接受正念认知疗法后的临床改善与恐惧网络中的结构性影像组学变化有关，尤其是岛叶的变化。 本页面由土耳其语自动翻译。 [阅读原文](https://alisanburak.com/wcp-2026-posterler/so362) 本页是借助人工智能编写的土耳其语摘要，介绍在第26届世界精神病学大会上报告的研究。研究归报告作者所有；引用时请查阅原始来源。 SO362 简短口头壁报报告神经科学与影像学随机对照试验 # 惊恐障碍患者接受正念认知疗法后临床症状改善的结构性精神影像组学特征：一项随机对照试验 STRUCTURAL PSYCHORADIOMIC FEATURES OF CLINICAL SYMPTOM IMPROVEMENT FOLLOWING MINDFULNESS-BASED COGNITIVE THERAPY IN PATIENTS WITH PANIC DISORDER: A RANDOMIZED CONTROLLED TRIAL 报告人: Hyun-Ju Kim 国家: Korea, Republic of 机构: CHA Bundang Medical Center, Department of Psychiatry 分会场会议: 3910 - PARALLEL SHORT ORAL POSTER SESSIONS: MOOD & ANXIETY DISORDERS - Part III 日期: Fri, 25.09.2026 惊恐障碍患者接受正念认知疗法后的临床改善与恐惧网络中的结构性影像组学变化有关，尤其是岛叶的变化。 本研究旨在确定与惊恐障碍（panic disorder，PD）患者接受正念认知疗法（mindfulness-based cognitive therapy，MBCT）后临床改善相关的结构磁共振成像（MRI）影像组学特征。这项为期八周的随机对照试验纳入了43名惊恐障碍患者，将其分为MBCT联合药物治疗组（n=23）和单纯药物治疗组（n=20）；在基线和第8周使用惊恐障碍症状量表（Panic Disorder Symptom Scale，PDSS）及焦虑敏感性指数修订版（Anxiety Sensitivity Index-Revised，ASI-R）进行评估，并采集T1加权磁共振图像。使用Destrieux图谱和PyRadiomics，从恐惧网络的20个区域（岛叶、海马、前扣带皮质、腹内侧前额叶皮质）中提取每次扫描的2,140项影像组学特征；分析采用线性混合效应模型（linear mixed-effects modeling，LMM）、变化分数的Welch检验筛选、采用留一法交叉验证（leave-one-out cross-validation，LOOCV）的随机森林（random forest）分类器、SHAP和Pearson相关分析。LMM分析显示，PDSS（F=24.702；p<0.001）和ASI-R（F=23.097；p<0.001）均存在显著的时间效应；PDSS（F=3.290；p=0.023；效应量［effect size］ηp²=0.076）和ASI-R（F=4.857；p=0.003；ηp²=0.110）均存在显著的组别与时间交互作用，效应量为中等。在提取的2,140项变化特征中，213项存在组间差异（p<0.05）；随机森林模型经LOOCV验证，曲线下面积（AUC）为0.85，准确率为0.78。SHAP分析显示，岛叶和额叶特征占主导地位，右侧前岛叶组织异质性的降低提示了与MBCT相关的变化；在MBCT联合药物治疗组中，PDSS的变化与右侧海马形状（球形度）的变化相关（r=0.561；p=0.0053），ASI-R的变化则与右侧岛叶灰度大小区域矩阵（GLSZM）特征的变化相关（r=0.444；p=0.034）。综上，结构性影像组学变化，尤其是岛叶内的变化，与惊恐障碍患者接受MBCT后的临床改善有关；基于T1加权成像的结构性影像组学测量可提供补充性的神经生物学标志物，从而为精准精神医学（precision psychiatry）作出贡献。 [查看原始壁报](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/902) 如何引用本研究？ APA 7： Kim, H-J., et al. (2026, September 25). Structural psychoradiomic features of clinical symptom improvement following mindfulness-based cognitive therapy in patients with panic disorder: a randomized controlled trial [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/902 Vancouver： Kim HJ, et al. Structural psychoradiomic features of clinical symptom improvement following mindfulness-based cognitive therapy in patients with panic disorder: a randomized controlled trial [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/902 作者姓名和标题格式由大会系统自动生成；使用前请与原始海报核对。 ## 相关主题 - [5-HTTLPR ve MAOA genotiplerinin Iowa kumar görevinde risk altında karar verme üzerindeki farklı duyarlılık etkileri](https://alisanburak.com/zh/wcp-2026-posterler/ev0042) - [Duygusal düzensizliği olan erişkin DEHB hastalarında merkezi noradrenalin taşıyıcısı erişilebilirliğinin [11C]MRB PET/MRI ile in vivo görüntülenmesi ve nicelenmesi](https://alisanburak.com/zh/wcp-2026-posterler/ev0065) - [Erişkin DEHB'de sapmış beyin kritikliği: uzun erimli zamansal korelasyonlar ve görüntüleme transkriptomiğinden çıkarımlar](https://alisanburak.com/zh/wcp-2026-posterler/ev0067) - [Anksiyete biyobelirteci olarak fibroblast büyüme faktörü 2: tehdide yönelik dikkat yanlılığıyla ilişkileri](https://alisanburak.com/zh/wcp-2026-posterler/ev0120) - [Trajedi paradoksu: hüzünlü müzikle olumlu duygudurum düzenlenmesinin psikolojik ve nörobiyolojik mekanizmaları](https://alisanburak.com/zh/wcp-2026-posterler/ev0134) [全部 WCP 2026 摘要](https://alisanburak.com/zh/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/zh/wcp-2026-posterler/so362 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim