# 经前烦躁障碍中选择性孕激素受体调节后的别孕烯醇酮水平与症状改善

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- Page title: 经前烦躁障碍中选择性孕激素受体调节后的别孕烯醇酮水平与症状改善 | WCP 2026 摘要

> 选择性孕激素受体调节剂显著降低了黄体期别孕烯醇酮水平，但症状改善与其变化幅度无关。

本页面由土耳其语自动翻译。 [阅读原文](https://alisanburak.com/wcp-2026-posterler/so286)

本页是借助人工智能编写的土耳其语摘要，介绍在第26届世界精神病学大会上报告的研究。研究归报告作者所有；引用时请查阅原始来源。

SO286

简短口头壁报报告围产期与女性健康随机对照试验的二次分析

# 经前烦躁障碍中选择性孕激素受体调节后的别孕烯醇酮水平与症状改善

ALLOPREGNANOLONE AND SYMPTOM IMPROVEMENT IN PREMENSTRUAL DYSPHORIC DISORDER FOLLOWING SELECTIVE PROGESTERONE RECEPTOR MODULATION

报告人: Ylva Walldén

国家: Sweden

机构: Uppsala University, Department of Women's and Children's Health

分会场会议: 3660 - PARALLEL SHORT ORAL POSTER SESSIONS: PSYCHOPHARMACOLOGY - Part II

日期: Fri, 25.09.2026

选择性孕激素受体调节剂显著降低了黄体期别孕烯醇酮水平，但症状改善与其变化幅度无关。

本研究旨在考察选择性孕激素受体调节剂（selective progesterone receptor modulator，SPRM）治疗对血清别孕烯醇酮（ALLO）水平的影响，并评估别孕烯醇酮的变化是否与心境症状的改善有关。样本包括38名参与者，来自一项针对符合DSM经前烦躁障碍（premenstrual dysphoric disorder，PMDD）诊断标准的女性开展的随机对照试验（randomized controlled trial，RCT）；参与者在三个月经周期内接受SPRM（醋酸乌利司他，n=20）或安慰剂（n=18）治疗。研究在治疗前及第三个治疗周期结束时的黄体晚期采集血样，采用超高效超临界流体色谱串联质谱法测定血清ALLO水平，使用每日问题严重程度记录表（daily record of severity of problems，DRSP）评估PMDD症状，并通过一般线性模型比较ALLO水平。从基线到治疗结束，治疗组和安慰剂组的别孕烯醇酮水平均有所下降；时间与治疗之间存在显著交互作用，表明SPRM组的降幅大于安慰剂组（F(1, 36)=9.74；p=0.004；偏η平方，partial eta squared=0.21）。别孕烯醇酮的变化与治疗后的PMDD症状严重程度无关（p=0.28）。作者得出结论：选择性孕激素受体调节可显著降低黄体期别孕烯醇酮水平，而症状改善似乎更多与激素趋于稳定有关，而非与其变化幅度有关；这一发现支持了PMDD患者神经类固醇敏感性发生改变的假说。

[查看原始壁报](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1175)

如何引用本研究？

APA 7： Walldén, Y., et al. (2026, September 25). Allopregnanolone and symptom improvement in premenstrual dysphoric disorder following selective progesterone receptor modulation [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1175

Vancouver： Walldén Y, et al. Allopregnanolone and symptom improvement in premenstrual dysphoric disorder following selective progesterone receptor modulation [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1175

作者姓名和标题格式由大会系统自动生成；使用前请与原始海报核对。

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