# 全谱大麻提取物对急性疼痛的选择性作用：临床试验 - URL: https://alisanburak.com/zh/wcp-2026-posterler/ev1113 - Language: zh - Last updated: not specified - Page title: 全谱大麻提取物对急性疼痛的选择性作用：临床试验 | WCP 2026 摘要 > 在实验性热痛中，全谱大麻提取物仅减轻了疼痛的情绪不适维度，未改变感觉阈值和耐受值。 本页面由土耳其语自动翻译。 [阅读原文](https://alisanburak.com/wcp-2026-posterler/ev1113) 本页是借助人工智能编写的土耳其语摘要，介绍在第26届世界精神病学大会上报告的研究。研究归报告作者所有；引用时请查阅原始来源。 EV1113 电子海报精神药理学随机对照试验 # 全谱大麻提取物对急性疼痛的选择性作用：临床试验 SELECTIVE EFFECTS OF FULL-SPECTRUM CANNABIS EXTRACT ON ACUTE PAIN: CLINICAL TRIAL 报告人: Flávia De Lima Osório 国家: Brazil 机构: Ribeirão Preto Medical School, University of São Paulo (FMRP-USP) 在实验性热痛中，全谱大麻提取物仅减轻了疼痛的情绪不适维度，未改变感觉阈值和耐受值。 本研究旨在评估全谱大麻提取物（full spectrum cannabis extract，FSCE；CBD:THC = 40:1）对健康成年人实验性诱发的热痛感知的影响。研究采用随机、交叉、双盲、安慰剂对照设计；70名健康成年人（男性占43%，平均年龄31.3岁）在间隔15天洗脱期的两次试验中，分别口服1 mL FSCE和安慰剂。采用接触式温度刺激仪逐步升温（每5秒升高1摄氏度）诱发疼痛；主要终点为感知阈值、耐受性、疼痛强度及疼痛不适感，次要终点为安全性和耐受性；按照意向性治疗原则，使用线性混合效应模型进行分析。结果显示，疼痛不适感显著降低15.91%（p < 0.01）；疼痛强度降低20.17%，但仅呈趋势，未达到统计学显著性（p = 0.06）。首次感知时间（增加3.78%；p = 0.55）、首次感知温度（增加0.24%；p = 0.75）、疼痛耐受时间（减少0.51%；p = 0.80）及疼痛耐受温度（降低0.32%；p = 0.49）均无显著变化。失访率为5.7%，安全性与安慰剂相当（p = 0.56）。综上，FSCE的镇痛作用似乎更多地通过情绪调节和减轻情感性痛苦实现，而非直接阻断感觉；对于疼痛情绪维度较为突出的临床情况（慢性疼痛、纤维肌痛、共病焦虑或抑郁的疼痛），FSCE被认为是一种有前景的选择。 [查看原始壁报](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/390) 如何引用本研究？ APA 7： Osório, F. D. L., et al. (2026, September 23-26). Selective effects of full-spectrum cannabis extract on acute pain: clinical trial [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/390 Vancouver： Osório FDL, et al. Selective effects of full-spectrum cannabis extract on acute pain: clinical trial [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/390 作者姓名和标题格式由大会系统自动生成；使用前请与原始海报核对。 ## 相关主题 - [Açığı kapatmak: erişkin DEHB ilacı başlanmadan önce EKG sevk uyumunun iyileştirilmesi, kapalı döngü klinik denetim](https://alisanburak.com/zh/wcp-2026-posterler/ev0088) - [Anksiyete bozukluğu olan hastalarda psikobiyotik müdahalesi: ısıl işlem görmüş Lactobacillus paracasei PS23'ün etkilerini inceleyen çift kör randomize kontrollü çalışma](https://alisanburak.com/zh/wcp-2026-posterler/ev0126) - [Otizm spektrum bozukluğunda bumetanidin tedavi edici potansiyeli: güncel kanıtlar ve gelecek yönelimleri](https://alisanburak.com/zh/wcp-2026-posterler/ev0157) - [Verbaskozid ile otizm spektrum bozukluğu tedavisinin mekanizmaları: ağ farmakolojisi, moleküler yerleştirme ve moleküler dinamik temelli inceleme](https://alisanburak.com/zh/wcp-2026-posterler/ev0172) - [Otizm spektrum bozukluğunun çekirdek belirtilerinin tedavisinde kannabidiol: sistematik derleme](https://alisanburak.com/zh/wcp-2026-posterler/ev0186) [全部 WCP 2026 摘要](https://alisanburak.com/zh/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/zh/wcp-2026-posterler/ev1113 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim