# 首发与复发性重性抑郁障碍中局部神经活动及功能连接密度的变化：一项静息态fMRI研究 - URL: https://alisanburak.com/zh/wcp-2026-posterler/ev0823 - Language: zh - Last updated: not specified - Page title: 首发与复发性重性抑郁障碍中局部神经活动及功能连接密度的变化：一项静息态fMRI研究 | WCP 2026 摘要 > 研究发现，复发性重性抑郁障碍患者左侧前扣带皮层的功能连接密度升高，是其区别于首发患者及健康对照者的特征。 本页面由土耳其语自动翻译。 [阅读原文](https://alisanburak.com/wcp-2026-posterler/ev0823) 本页是借助人工智能编写的土耳其语摘要，介绍在第26届世界精神病学大会上报告的研究。研究归报告作者所有；引用时请查阅原始来源。 EV0823 电子海报神经科学与影像学横断面研究 # 首发与复发性重性抑郁障碍中局部神经活动及功能连接密度的变化：一项静息态fMRI研究 ALTERATIONS IN LOCAL NEURAL ACTIVITY AND FUNCTIONAL CONNECTIVITY DENSITY IN FIRST-EPISODE AND RECURRENT MAJOR DEPRESSIVE DISORDER: A RESTING-STATE FMRI STUDY 报告人: Shaojia Lu 国家: China 机构: Zhejiang University School of Medicine, The First Affiliated Hospital, Department of Psychiatry 研究发现，复发性重性抑郁障碍患者左侧前扣带皮层的功能连接密度升高，是其区别于首发患者及健康对照者的特征。 本研究旨在比较复发性重性抑郁障碍（recurrent major depressive disorder，RMDD）与首发重性抑郁障碍（first-episode major depressive disorder，FMDD）患者的自发脑活动差异，以阐明疾病复发与进展的机制。研究共纳入99名参与者：33名FMDD患者、20名RMDD患者及46名健康对照者（healthy control，HC）。所有参与者均接受静息态功能磁共振成像检查；使用DPABI对数据进行预处理，并计算局部神经活动的四维时空一致性（four-dimensional spatial-temporal consistency of local neural activity，FOCA）及功能连接密度（functional connectivity density，FCD）指标；以年龄、性别及平均帧间位移为协变量，采用协方差分析（ANCOVA）评估组间差异，随后提取感兴趣区数据，并分析其与临床指标的相关性。与健康对照组相比，FMDD组和RMDD组的左侧顶上回FOCA均降低；此外，与FMDD组及HC组相比，RMDD组右侧额下回的FOCA、左侧前扣带皮层（anterior cingulate cortex，ACC）的全局及局部FCD，以及右侧海马旁回的局部FCD均显著升高。左侧ACC的异常FCD值与发作次数及Snaith-Hamilton快感量表（Snaith-Hamilton Pleasure Scale，SHAPS）评分呈正相关：全局FCD与发作次数的相关性为r = 0.584，p = 0.011；局部FCD与发作次数的相关性为r = 0.691，p = 0.002；全局FCD与SHAPS评分的相关性为r = 0.692，p = 0.001；局部FCD与SHAPS评分的相关性为r = 0.708，p = 0.001。所有体素簇均通过AlphaSim校正（p < 0.01，簇大小 > 23个体素）。作者认为，这些结果反映了FMDD与RMDD中不同的功能改变，并提出左侧ACC功能连接增强可能是RMDD功能紊乱的核心特征。 [查看原始壁报](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/193) 如何引用本研究？ APA 7： Lu, S. (2026, September 23-26). Alterations in local neural activity and functional connectivity density in first-episode and recurrent major depressive disorder: a resting-state fmri study [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/193 Vancouver： Lu S. Alterations in local neural activity and functional connectivity density in first-episode and recurrent major depressive disorder: a resting-state fmri study [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/193 作者姓名和标题格式由大会系统自动生成；使用前请与原始海报核对。 ## 相关主题 - [5-HTTLPR ve MAOA genotiplerinin Iowa kumar görevinde risk altında karar verme üzerindeki farklı duyarlılık etkileri](https://alisanburak.com/zh/wcp-2026-posterler/ev0042) - [Duygusal düzensizliği olan erişkin DEHB hastalarında merkezi noradrenalin taşıyıcısı erişilebilirliğinin [11C]MRB PET/MRI ile in vivo görüntülenmesi ve nicelenmesi](https://alisanburak.com/zh/wcp-2026-posterler/ev0065) - [Erişkin DEHB'de sapmış beyin kritikliği: uzun erimli zamansal korelasyonlar ve görüntüleme transkriptomiğinden çıkarımlar](https://alisanburak.com/zh/wcp-2026-posterler/ev0067) - [Anksiyete biyobelirteci olarak fibroblast büyüme faktörü 2: tehdide yönelik dikkat yanlılığıyla ilişkileri](https://alisanburak.com/zh/wcp-2026-posterler/ev0120) - [Trajedi paradoksu: hüzünlü müzikle olumlu duygudurum düzenlenmesinin psikolojik ve nörobiyolojik mekanizmaları](https://alisanburak.com/zh/wcp-2026-posterler/ev0134) [全部 WCP 2026 摘要](https://alisanburak.com/zh/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/zh/wcp-2026-posterler/ev0823 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim