# Disrupted macroscopic intrinsic brain dynamics in major depressive disorder - URL: https://alisanburak.com/en/wcp-2026-posterler/so422 - Language: en - Last updated: not specified - Page title: Disrupted macroscopic intrinsic brain dynamics in major depressive disorder | WCP 2026 Summary > Intrinsic brain dynamics are disrupted in major depressive disorder, showing an imbalance between sensory and association systems, and these alterations are as… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so422) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. SO422 Brief Oral Poster PresentationNeuroscience and ImagingCase-control imaging study # Disrupted macroscopic intrinsic brain dynamics in major depressive disorder DISRUPTED MACROSCOPIC INTRINSIC BRAIN DYNAMICS IN MAJOR DEPRESSIVE DISORDER Presenter: Fengmei Lu Country: China Institution: The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China Session: 4470 - PARALLEL SHORT ORAL POSTER SESSIONS: NEUROSCIENCE & NEUROIMAGING - Part V Date: Sat, 26.09.2026 Intrinsic brain dynamics are disrupted in major depressive disorder, showing an imbalance between sensory and association systems, and these alterations are associated with depression severity and anhedonia. The study aimed to characterize macroscopic intrinsic brain dynamics in major depressive disorder (MDD) using high-dimensional time-series features and to examine their clinical and molecular correlates. Resting-state functional magnetic resonance imaging (fMRI) data were collected from 159 patients with MDD and 126 matched healthy controls; features were extracted from regional blood oxygen level–dependent time series using the Highly Comparative Time Series Analysis (HCTSA) framework, two principal dimensions were identified using principal component analysis (PCA), and group differences were assessed at both the regional and network levels. Two principal components were identified: PC1, reflecting temporal dependence and stability, and PC2, reflecting amplitude distribution characteristics. At the regional level, patients with MDD showed decreased PC1 in the bilateral inferior occipital gyri and right postcentral gyrus and increased PC1 in the prefrontal cortex; PC2 was increased in the right inferior temporal gyrus and decreased in the right angular gyrus. At the network level, PC1 was increased in the default mode network and decreased in the visual network, while PC2 was increased in the frontoparietal network. Regarding clinical associations, PC2 in the right inferior temporal gyrus was positively associated with HAMD scores (R=0.274; q=0.030), while PC1 in the right dorsolateral superior frontal gyrus was positively associated with SHAPS scores, which measure anhedonia (R=0.288; q=0.027). The conference abstract also reports that imaging transcriptomic analysis revealed enrichment of PC1-associated patterns in synaptic and membrane processes, particularly in astrocytes. The findings indicate disrupted macroscopic brain dynamics in MDD, reflecting an imbalance between sensory and association systems, and suggest that distinct aspects of temporal organization may jointly contribute to the clinical heterogeneity of the disorder. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/642) How to cite this study APA 7: Lu, F., et al. (2026, September 26). Disrupted macroscopic intrinsic brain dynamics in major depressive disorder [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/642 Vancouver: Lu F, et al. Disrupted macroscopic intrinsic brain dynamics in major depressive disorder [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. 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