# Ketamine as a rapid intervention for suicidal ideation: evidence and trends in mental health research - URL: https://alisanburak.com/en/wcp-2026-posterler/so365 - Language: en - Last updated: not specified - Page title: Ketamine as a rapid intervention for suicidal ideation: evidence and trends in mental health research | WCP 2026 Summary > Intravenous ketamine rapidly reduces suicidal ideation, usually within 24 hours, but this effect is not synonymous with a demonstrated suicide prevention effec… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so365) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. SO365 Brief Oral Poster PresentationSuicide and CrisisA systematic review of systematic reviews # Ketamine as a rapid intervention for suicidal ideation: evidence and trends in mental health research KETAMINE AS A RAPID INTERVENTION FOR SUICIDAL IDEATION: EVIDENCE AND TRENDS IN MENTAL HEALTH RESEARCH Presenter: Karine V. Ferreira Country: Brazil Institution: Municipal Health Department of Araguari Session: 3910 - PARALLEL SHORT ORAL POSTER SESSIONS: MOOD & ANXIETY DISORDERS - Part III Date: Fri, 25.09.2026 Intravenous ketamine rapidly reduces suicidal ideation, usually within 24 hours, but this effect is not synonymous with a demonstrated suicide prevention effect. The study asks what the core evidence is for ketamine’s effect on suicidal ideation; because time is a critical clinical variable in a suicidal crisis, the focus is on speed of response, specificity of the effect, and implications for care. The method is a systematic review of systematic reviews and meta-analyses; within the PICO framework, the population is adults with suicidal ideation, the intervention is ketamine or esketamine (IV, IN, SC), the comparator is placebo, usual care, or antidepressants, and the outcome is a reduction in suicidal ideation. MEDLINE, PsycINFO, Embase, CENTRAL, Scopus, LILACS, ClinicalTrials.gov, and Google Scholar were searched; 111 records were identified, and after 103 were screened, 58 full-text articles were considered potentially eligible; AMSTAR 2, corrected covered area (CCA), and GRADE were used in the assessment, and the protocol was registered in PROSPERO under CRD420261475986. The reference meta-analysis is based on 15 independent studies, 25 reports, and 572 participants, and reports a beneficial effect with moderate-to-low certainty. The main finding is that the most consistent signal for a specific reduction in suicidal ideation is associated with intravenous ketamine, with the effect usually emerging within 24 hours; intranasal esketamine produces rapid improvement in depressive symptoms during periods of acute suicide risk, but its specific effect on suicidal ideation is less consistent. Factors limiting interpretation include heterogeneity in populations, doses, routes of administration, and measurement instruments, frequently small samples, generally short follow-up periods, and overlap of primary studies across reviews; in addition, Ferreira’s (2024) bibliometric review identified 12,928 publications on ketamine in mental health, with publication output peaking in 2022. The poster emphasizes that a reduction in suicidal ideation cannot be equated with demonstrated suicide prevention, and that suicide attempts and deaths require evidence in their own right. In conclusion, ketamine is supported as a rapid-acting intervention, but is positioned as part of a broader treatment strategy that includes clinical selection criteria, a trained team and an appropriate setting, monitoring during and after administration, risk management and a safety plan, and longitudinal follow-up. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1144) How to cite this study APA 7: Ferreira, K. V., et al. (2026, September 25). Ketamine as a rapid intervention for suicidal ideation: evidence and trends in mental health research [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1144 Vancouver: Ferreira KV, et al. Ketamine as a rapid intervention for suicidal ideation: evidence and trends in mental health research [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. 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