# Striatal serotonin 2A receptor availability and functional network organization in major depressive disorder - URL: https://alisanburak.com/en/wcp-2026-posterler/so246 - Language: en - Last updated: not specified - Page title: Striatal serotonin 2A receptor availability and functional network organization in major depressive disorder | WCP 2026 Summary > Striatal 5-HT2A receptor binding potential is increased in drug-naive patients with major depressive disorder, and this increase is associated with disrupted n… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so246) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. SO246 Kısa Sözlü Poster SunumuNörobilim ve GörüntülemeKesitsel olgu kontrol görüntüleme çalışması # Striatal serotonin 2A receptor availability and functional network organization in major depressive disorder STRIATAL SEROTONIN 2A RECEPTOR AVAILABILITY AND FUNCTIONAL NETWORK ORGANIZATION IN MAJOR DEPRESSIVE DISORDER Sunan: Jong-Hoon Kim Ülke: Korea, Republic of Kurum: Gachon University College of Medicine, Gil Medical Center, Department of Psychiatry Oturum: 3580 - PARALLEL SHORT ORAL POSTER SESSIONS: NEUROSCIENCE & NEUROIMAGING - Part III Tarih: Fri, 25.09.2026 Striatal 5-HT2A receptor binding potential is increased in drug-naive patients with major depressive disorder, and this increase is associated with disrupted network organization. The aim was to jointly examine regional serotonin 2A receptor (5-HT2AR) availability and functional network organization in drug-naive patients with major depressive disorder (MDD). The study included 21 drug-naive patients with MDD diagnosed using the MINI-Plus and 25 healthy controls; depressive symptoms were assessed using the HAMD-17 and BDI. Participants underwent positron emission tomography (PET) with [11C]MDL100907 and resting-state functional magnetic resonance imaging. Binding potential (BPND) was calculated in 22 predefined regions, followed by functional connectivity and graph theory analyses. The groups were similar in age (37.1 (11.2) and 32.1 (7.5); p=0.090) and sex (p=0.592). In patients, the HAMD-17 score was 20.5 (3.6), and the BDI score was 26.6 (8.7), compared with 3.5 (3.0) in controls (p<0.001). BPND was higher in the MDD group than in controls in the right hippocampus, right amygdala, right caudate, and bilateral putamen (Bonferroni threshold p<0.00227). No significant differences in functional connectivity remained after false discovery rate (FDR) correction. Uncorrected analyses showed reduced connectivity between the right caudate and the right putamen (t=-3.99; p_unc<0.001; p_FDR=0.164), right anterior insula (t=-2.54; p_unc=0.015), and left anterior insula (t=-2.44; p_unc=0.019) (cluster mass 66.94; p_unc=0.035; p_FDR=0.598). Graph analyses showed reduced closeness centrality in the right putamen and right rostral prefrontal cortex in MDD (t=-3.75 and t=-3.70; p_FDR=0.011), increased average path length (right putamen t=4.78, p_FDR<0.001; left putamen t=3.73, p_FDR=0.010; right rostral prefrontal cortex t=3.31, p_FDR=0.023), and increased eccentricity in the anterior cingulate cortex, right putamen, and anterior cerebellum (t=3.81, 3.72, and 3.28; p_FDR=0.010, 0.010, and 0.025). Elevated putaminal BPND was associated with reduced network integration in an exploratory analysis (p_unc<0.05). The authors report that striatal 5-HT2AR alterations are linked to disrupted network organization in MDD and suggest a possible molecular basis underlying large-scale network dysfunction. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1343) Bu çalışmaya nasıl atıf yapılır? APA 7: Kim, J-H., et al. (2026, September 25). Striatal serotonin 2a receptor availability and functional network organization in major depressive disorder [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1343 Vancouver: Kim JH, et al. Striatal serotonin 2a receptor availability and functional network organization in major depressive disorder [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1343 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [5-HTTLPR ve MAOA genotiplerinin Iowa kumar görevinde risk altında karar verme üzerindeki farklı duyarlılık etkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0042) - [Duygusal düzensizliği olan erişkin DEHB hastalarında merkezi noradrenalin taşıyıcısı erişilebilirliğinin [11C]MRB PET/MRI ile in vivo görüntülenmesi ve nicelenmesi](https://alisanburak.com/en/wcp-2026-posterler/ev0065) - [Erişkin DEHB'de sapmış beyin kritikliği: uzun erimli zamansal korelasyonlar ve görüntüleme transkriptomiğinden çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0067) - [Anksiyete biyobelirteci olarak fibroblast büyüme faktörü 2: tehdide yönelik dikkat yanlılığıyla ilişkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0120) - [Trajedi paradoksu: hüzünlü müzikle olumlu duygudurum düzenlenmesinin psikolojik ve nörobiyolojik mekanizmaları](https://alisanburak.com/en/wcp-2026-posterler/ev0134) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/so246 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim