# Non-invasive brain stimulation in children and adolescents: a systematic review in the Indian context

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- Page title: Non-invasive brain stimulation in children and adolescents: a systematic review in the Indian context | WCP 2026 Summary

> A synthesis of 16 studies on non-invasive brain stimulation in children and adolescents in India indicates a generally favorable safety profile, but diagnosis-…

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This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it.

SO197

Brief Oral Poster PresentationNeuromodulationSystematic review

# Non-invasive brain stimulation in children and adolescents: a systematic review in the Indian context

NON-INVASIVE BRAIN STIMULATION IN CHILDREN AND ADOLESCENTS: A SYSTEMATIC REVIEW IN THE INDIAN CONTEXT

Presenter: Priyadeep Zamindar

Country: India

Institution: National Institute of Mental Health and Neuro Sciences, Department of Child & Adolescent Psychiatry

Session: 3070 - PARALLEL SHORT ORAL POSTER SESSIONS: CHILD & DEVELOPMENTAL PSYCHIATRY 03

Date: Thu, 24.09.2026

A synthesis of 16 studies on non-invasive brain stimulation in children and adolescents in India indicates a generally favorable safety profile, but diagnosis-specific and heterogeneous efficacy signals.

The aim is to synthesize evidence from India on the use, tolerability, safety, and efficacy of non-invasive brain stimulation (NIBS) techniques in individuals aged 18 years and younger. The methodology is a PRISMA 2020-compliant, PROSPERO-registered systematic review; seven databases and manual searching were used, 532 records were screened, 143 duplicates were removed, 389 records were assessed at the title and abstract level (346 excluded), 43 full texts were reviewed (27 excluded), and 16 studies were included. Risk of bias was assessed using RoB 2.0, NHLBI, and JBI tools, and a narrative synthesis was conducted because heterogeneity precluded meta-analysis. Of the included studies, five used transcranial direct current stimulation (tDCS), and 11 used repetitive transcranial magnetic stimulation, theta burst stimulation, or deep TMS (rTMS/TBS/dTMS). Study designs comprised seven randomized controlled trials, three open-label studies, and six case reports or case series, covering nine diagnostic categories, with sample sizes ranging from 1 to 61. The studies were conducted between 2015 and 2025 and were concentrated at three centers (NIMHANS, CIP Ranchi, AIIMS Delhi). Findings by diagnosis were as follows: favorable results for rTMS combined with constraint-induced movement therapy in cerebral palsy (n=1); promising antidepressant effects with TBS and tDCS in depression and bipolar disorder, but with a risk of affective switching (n=3); promising improvements in executive function with anodal tDCS in ADHD, although the study was unblinded and lacked a sham control (n=1); favorable improvements in BFCRS and AHRS scores in catatonia and neuroleptic malignant syndrome (n=2); mixed findings in obsessive-compulsive disorder (n=3) and schizophrenia (n=3); no change in ISAA scores with low-frequency unilateral rTMS in autism spectrum disorder (n=50); no change on any measure with low-frequency vertex rTMS in focal epilepsy; and no benefit from high-frequency rTMS in mania (the dose was noted to be subtherapeutic). Regarding safety, the most serious adverse event was a single seizure associated with iTBS in adolescent schizophrenia. Treatment-emergent affective switching was reported at a rate of 7.7% with TBS in adolescent depression and was not limited to bipolar disorder. The conference abstract reports a total of four cases of affective switching across tDCS and TBS studies, with transient headache and scalp pain or tingling being the most common side effects. In conclusion, the evidence supports efficacy but is heterogeneous, safety is generally favorable, the strongest efficacy signal is for rTMS combined with constraint-induced movement therapy in cerebral palsy, and adequately powered sham-controlled studies are needed.

[View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/798)

How to cite this study

APA 7: Zamindar, P., et al. (2026, September 24). Non-invasive brain stimulation in children and adolescents: a systematic review in the indian context [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/798

Vancouver: Zamindar P, et al. Non-invasive brain stimulation in children and adolescents: a systematic review in the indian context [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/798

Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use.

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