# Biological modulation of emotional vulnerability in borderline personality disorder: a randomized sham-controlled vagal stimulation study - URL: https://alisanburak.com/en/wcp-2026-posterler/so189 - Language: en - Last updated: not specified - Page title: Biological modulation of emotional vulnerability in borderline personality disorder: a randomized sham-controlled vagal stimulation study | WCP 2026 Summary > A single session of active transcutaneous auricular vagus nerve stimulation reduced reported negative affect during emotion induction in women with borderline… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so189) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. SO189 Kısa Sözlü Poster SunumuKişilik BozukluklarıRKÇ (tek seans, sham kontrollü) # Biological modulation of emotional vulnerability in borderline personality disorder: a randomized sham-controlled vagal stimulation study BIOLOGICAL MODULATION OF EMOTIONAL VULNERABILITY IN BORDERLINE PERSONALITY DISORDER: A RANDOMIZED SHAM-CONTROLLED VAGAL STIMULATION STUDY Sunan: Giuseppe Guerriero Ülke: Sweden Oturum: 3060 - PARALLEL SHORT ORAL POSTER SESSIONS: PERSONALITY DISORDERS Tarih: Thu, 24.09.2026 A single session of active transcutaneous auricular vagus nerve stimulation reduced reported negative affect during emotion induction in women with borderline personality disorder compared with sham stimulation, but this effect was not reflected in peripheral autonomic measures. The study examined whether a single session of transcutaneous auricular vagus nerve stimulation (taVNS) reduced self-reported negative affect in emotional vulnerability, a core feature of borderline personality disorder (BPD), and explored whether the effect was also evident in peripheral autonomic markers. In a randomized, single-blind, sham-controlled, single-session laboratory design (NCT05892900), 34 women aged 18 to 50 years with a DSM-5 diagnosis of BPD established using the SCID-5-PD were assigned to active (n=16) or sham (n=18) stimulation, with no dropouts. Stimulation was delivered at 25 Hz in cycles of 28 seconds on and 32 seconds off, at 0.9±0.8 mA; the cymba conchae was stimulated in the active arm and the earlobe in the sham arm. Emotion induction involved one neutral and three negative 4-minute films, with the negative films presented in random order; negative affect was measured using the PANAS after each film and 4 minutes after the negative films. The primary analysis used a mixed-effects model adjusted for baseline affect and film intensity, while physiological recordings using ECG and electrodermal activity (EDA) provided heart rate, lnRMSSD, phasic EDA frequency, and tonic skin conductance level (SCL). Active taVNS was associated with lower negative affect throughout the paradigm: F(1; 36.44)=5.74; p=0.022; partial eta squared approximately 0.14; adjusted means of 17.25 versus 21.22, with a difference of -3.97 (95% confidence interval -7.33 to -0.61). The phase effect was significant (p<0.001), whereas the group-by-phase interaction was not (p=0.525); thus, the effect represented an overall downward shift rather than a change specific to a particular phase. No treatment effect was detected for heart rate (p=0.260), lnRMSSD (p=0.184), or phasic EDA (p=0.195); only the exploratory group-by-epoch interaction for tonic SCL was significant (p=0.011), and no serious adverse events were reported. The authors state that this is the first taVNS study in BPD, that the absence of a corresponding effect on peripheral autonomic arousal suggests that taVNS changes how bodily signals are integrated into emotional experience, that the findings are preliminary, and that there is no evidence of sustained clinical efficacy. Although the conference abstract reported increased heart rate variability and improved autonomic flexibility with taVNS, the poster indicates that no treatment effect was detected in peripheral autonomic measures; this account is based on the poster. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/879) Bu çalışmaya nasıl atıf yapılır? APA 7: Guerriero, G., et al. (2026, September 24). Biological modulation of emotional vulnerability in borderline personality disorder: a randomized sham-controlled vagal stimulation study [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/879 Vancouver: Guerriero G, et al. Biological modulation of emotional vulnerability in borderline personality disorder: a randomized sham-controlled vagal stimulation study [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/879 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [Otizm spektrum bozukluğu ve şizoid kişilik bozukluğu: ileri erişkinlikte tanısal karmaşıklık](https://alisanburak.com/en/wcp-2026-posterler/ev0152) - [Uyumsuz kişilik gelişimi olan ergenlerin belirlenmesine ilişkin ön deneyimler](https://alisanburak.com/en/wcp-2026-posterler/ev0256) - [ICD-11 sınır (borderline) örüntüsünün işlevselleştirilmesi: boyutsal şiddet, belirti ağları ve klinik uygulamada tanısal yararlılık](https://alisanburak.com/en/wcp-2026-posterler/ev0295) - [Dipp-11 (icd-11) kullanılarak dehb ve kişilik bozukluğu eş tanısının incelendiği bir pilot çalışma](https://alisanburak.com/en/wcp-2026-posterler/ev0303) - [Hallervorden Spatz hastalığında kişilik bozuklukları](https://alisanburak.com/en/wcp-2026-posterler/ev0343) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/so189 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. 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