# Just one simple question? Premenstrual symptoms as the key to precision medicine in perinatal depression - URL: https://alisanburak.com/en/wcp-2026-posterler/so172 - Language: en - Last updated: not specified - Page title: Just one simple question? Premenstrual symptoms as the key to precision medicine in perinatal depression | WCP 2026 Summary > In two independent population-based cohorts, reports of premenstrual symptoms before pregnancy were consistently associated with an increased risk of perinatal… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so172) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. SO172 Brief Oral Poster PresentationPerinatal and Women's HealthLongitudinal cohort (two population-based cohorts) # Just one simple question? Premenstrual symptoms as the key to precision medicine in perinatal depression ONE SIMPLE QUESTION? PREMENSTRUAL SYMPTOMS AS A KEY TO PRECISION MEDICINE IN PERINATAL DEPRESSION Presenter: Erika Comasco Country: Sweden Institution: Uppsala University, Department of Women's and Children's Health Session: 3020 - PARALLEL SHORT ORAL POSTER SESSIONS: PERINATAL & WOMEN'S HEALTH 01 Date: Thu, 24.09.2026 In two independent population-based cohorts, reports of premenstrual symptoms before pregnancy were consistently associated with an increased risk of perinatal depression, with the strongest association observed for premenstrual dysphoric disorder. The study aimed to characterize the relationship between premenstrual symptoms and the symptoms, dimensions, and trajectories of perinatal depression (PND) during pregnancy and the postpartum period within a precision medicine framework. Two independent population-based cohorts were used: BASIC (n = 4569) and Mom2B (n = 4591). PND symptoms were assessed longitudinally using the Edinburgh Postnatal Depression Scale (EPDS) at 17 and 32 weeks of pregnancy and at 6 weeks and 6 months postpartum in BASIC, and during the early, middle, and late stages of pregnancy and the postpartum period in Mom2B. Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) were identified retrospectively through self-report during pregnancy; analyses were adjusted for key confounders and replicated across both cohorts. In both cohorts, prior premenstrual symptom burden was consistently associated with an increased risk of PND. The odds of developing PND were up to 1.68 times higher among those reporting PMS (95% confidence interval 1.25 to 2.29; 6 to 13 weeks postpartum) and up to 3.05 times higher among those reporting PMDD (95% confidence interval 2.26 to 4.10; late pregnancy). Dimensional PND phenotypes involving moderate and severe symptoms of depressed mood, anxiety, and anhedonia were also associated with prior premenstrual symptoms. The authors report that sensitivity to ovarian hormones is a risk marker for PND across reproductive stages and that asking about premenstrual symptoms during pregnancy planning and early pregnancy can help identify women at risk and facilitate coordinated, multidisciplinary care planning. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2294) How to cite this study APA 7: Comasco, E., et al. (2026, September 24). One simple question? premenstrual symptoms as a key to precision medicine in perinatal depression [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2294 Vancouver: Comasco E, et al. One simple question? premenstrual symptoms as a key to precision medicine in perinatal depression [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2294 Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [Dikkatsizlik ve hiperaktivitenin ötesinde: kadınlarda DEHB'nin yeterince tedavi edilmeyen bir boyutu olarak duygusal disregülasyon](https://alisanburak.com/en/wcp-2026-posterler/ev0078) - [Gebelikte anne tiroid işlev bozukluğunun bebekte otizm spektrum bozukluğuyla ilişkisi: sistematik derleme ve meta-analiz](https://alisanburak.com/en/wcp-2026-posterler/ev0181) - [Hafif ve orta düzey obstetrik yük ile doğum sonrası kırk beşinci ayda boyutsal ruh sağlığı sonuçları](https://alisanburak.com/en/wcp-2026-posterler/ev0237) - [Portekiz toplumunda kabul görmeyen yas ölçeğinin geliştirilmesi ve geçerliğine ilişkin ön veriler](https://alisanburak.com/en/wcp-2026-posterler/ev0290) - [Gebelikte olumlu anne ruh sağlığı ile çocukta psikopatoloji ve sosyoduygusal gelişim: olası mekanizmalar ve yeni yönelimler](https://alisanburak.com/en/wcp-2026-posterler/ev0419) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/so172 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim