# Structural network alterations and peripheral immune and inflammatory dysregulation identify distinct subtypes with prognostic significance in major depressive disorder - URL: https://alisanburak.com/en/wcp-2026-posterler/so150 - Language: en - Last updated: not specified - Page title: Structural network alterations and peripheral immune and inflammatory dysregulation identify distinct subtypes with prognostic significance in major depressive disorder | WCP 2026 Summary > Two subtypes of major depressive disorder derived from structural covariance networks have distinct immune profiles, and the hyperconnectivity subtype responds… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so150) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. SO150 Brief Oral Poster PresentationNeuroscience and ImagingMendelian randomization and prospective cohort # Structural network alterations and peripheral immune and inflammatory dysregulation identify distinct subtypes with prognostic significance in major depressive disorder FRONTAL STRUCTURAL NETWORK VULNERABILITY AND PERIPHERAL IMMUNE DYSREGULATION IN MAJOR DEPRESSIVE DISORDER: DIAGNOSTIC AND PROGNOSTIC IMPLICATIONS Presenter: Wei Du Country: China Institution: West China Hospital of Sichuan University, Department of Radiology Session: 2840 - PARALLEL SHORT ORAL POSTER SESSIONS: NEUROSCIENCE & NEUROIMAGING - Part II Date: Thu, 24.09.2026 Two subtypes of major depressive disorder derived from structural covariance networks have distinct immune profiles, and the hyperconnectivity subtype responds more rapidly to antidepressants. The aim was to examine how peripheral immune dysregulation interacts with cortical structural patterns in major depressive disorder (MDD) and whether immune heterogeneity is modulated by brain structural networks. The study combined bidirectional Mendelian randomization (MR) with a prospective cohort design, using large-scale GWAS meta-analyses of MDD, UK Biobank gray matter volume (GMV) phenotypes, and 19 immune-related traits. In the cohort, 122 medication-naïve patients with MDD and 66 healthy controls underwent voxel-based morphometry, individualized structural covariance network analysis (IDSCN), and measurement of 40 peripheral inflammatory and immune markers; treatment response was assessed using machine learning and survival analysis. According to the main findings presented in the poster, MDD was genetically associated with lower IGF-1 levels (pFDR = 0.013), and IL-5 and leptin were associated with regional GMV (pFDR < 0.05). Network-level abnormalities were concentrated in connections between the default mode and limbic networks and within the limbic network. Patients were classified into two subtypes: the hypoconnectivity subtype (n = 49) was characterized by more pronounced anxiety and anhedonia, whereas the hyperconnectivity subtype (n = 73) showed a greater immune and inflammatory burden. During follow-up, antidepressant response was faster in the hyperconnectivity subtype (p = 0.032). The study concluded that these structurally derived subtypes reflect immune heterogeneity and may support biologically informed patient stratification and prognostic prediction; however, the conference abstract reported three subtypes, an AUC of 0.94, and an HR of 0.762 (p = 0.003), which are inconsistent with the poster. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2257) How to cite this study APA 7: Du, W., et al. (2026, September 24). Frontal structural network vulnerability and peripheral immune dysregulation in major depressive disorder: diagnostic and prognostic implications [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2257 Vancouver: Du W, et al. Frontal structural network vulnerability and peripheral immune dysregulation in major depressive disorder: diagnostic and prognostic implications [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. 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