# Lower resting-state functional connectivity between the hippocampus and the default mode network is associated with suicidal ideation - URL: https://alisanburak.com/en/wcp-2026-posterler/so148 - Language: en - Last updated: not specified - Page title: Lower resting-state functional connectivity between the hippocampus and the default mode network is associated with suicidal ideation | WCP 2026 Summary > Among patients experiencing a major depressive episode, resting-state functional connectivity between the right hippocampus and the default mode network is low… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so148) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. SO148 Brief Oral Poster PresentationNeuroscience and ImagingCross-sectional neuroimaging study # Lower resting-state functional connectivity between the hippocampus and the default mode network is associated with suicidal ideation LOWER RESTING STATE FUNCTIONAL CONNECTIVITY BETWEEN THE HIPPOCAMPUS AND DEFAULT NETWORK IS ASSOCIATED WITH SUICIDAL IDEATION. Presenter: Eyal Bergmann Country: Israel Institution: Columbia University Vagelos College of Physicians and Surgeons, Department of Psychiatry Session: 2840 - PARALLEL SHORT ORAL POSTER SESSIONS: NEUROSCIENCE & NEUROIMAGING - Part II Date: Thu, 24.09.2026 Among patients experiencing a major depressive episode, resting-state functional connectivity between the right hippocampus and the default mode network is lower in those with suicidal ideation than in those without. The aim was to elucidate the neural mechanism underlying suicidal ideation (SI) and to characterize its association with hippocampal functional connectivity (FC). In the discovery sample, 24 unmedicated adults with major depressive disorder and suicidal ideation, 10 without suicidal ideation, and 16 healthy volunteers underwent resting-state functional magnetic resonance imaging (fMRI); suicidal ideation was assessed using the Beck Scale for Suicide Ideation. Images were preprocessed using fMRIPrep and XCP Engine, seed-based connectivity was calculated from an a priori right hippocampal region of interest (MNI coordinates: 27, 21, 21, with the second and third values negative), and default mode network connectivity and within-network connectivity were estimated using the Yeo 7-network parcellation. The groups were similar in age (33.3 ± 10.6 versus 31.6 ± 7.2; p = .656), proportion of women (41.7% versus 60.0%; p = .467), years of education (15.9 ± 2.4 versus 16.3 ± 2.1; p = .654), HAM-D scores excluding the suicide item (17.8 ± 5.3 versus 16.2 ± 4.1; p = .388), and mean head motion (mean FD 0.083 ± 0.024 versus 0.093 ± 0.028; p = .318). The connectivity pattern of the hippocampal region of interest spatially overlapped with the default mode network, and connectivity between the hippocampus and the default mode network was significantly lower in the group with suicidal ideation; in contrast, no significant association was found between within-default mode network connectivity and suicidal ideation. The finding was replicated in the independent, larger REST-MDD dataset (n = 218; 160 with suicidal ideation and 58 without; adjusting for age, sex, HAM-D, FD, and site as covariates); in this sample, HAM-D scores were also higher among those with suicidal ideation (21.4 ± 5.0 versus 19.6 ± 4.3; p = .008). In conclusion, hippocampal resting-state connectivity is associated with the presence of suicidal ideation, and this association is specific to hippocampal connectivity rather than within-default mode network connectivity. The authors note that further studies should investigate whether this measure reflects a state or a trait, whether it is specific to major depression or transdiagnostic, and how it relates to suicidal behavior. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/377) How to cite this study APA 7: Bergmann, E., et al. (2026, September 24). Lower resting state functional connectivity between the hippocampus and default network is associated with suicidal ideation [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/377 Vancouver: Bergmann E, et al. Lower resting state functional connectivity between the hippocampus and default network is associated with suicidal ideation [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. 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