# Gut microbiota alterations in major depressive disorder: a systematic review and clinical implications - URL: https://alisanburak.com/en/wcp-2026-posterler/so145 - Language: en - Last updated: not specified - Page title: Gut microbiota alterations in major depressive disorder: a systematic review and clinical implications | WCP 2026 Summary > Gut microbiota alterations in major depressive disorder are supported by clinical evidence, and the gut–brain axis is emerging as a biologically plausible targ… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so145) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. SO145 Brief Oral Poster PresentationMood and AnxietySystematic review # Gut microbiota alterations in major depressive disorder: a systematic review and clinical implications ALTERATIONS IN GUT MICROBIOTA IN MAJOR DEPRESSIVE DISORDER: A SYSTEMATIC REVIEW AND CLINICAL IMPLICATIONS Presenter: Igor P. Oliveira Country: Brazil Session: 2840 - PARALLEL SHORT ORAL POSTER SESSIONS: NEUROSCIENCE & NEUROIMAGING - Part II Date: Thu, 24.09.2026 Gut microbiota alterations in major depressive disorder are supported by clinical evidence, and the gut–brain axis is emerging as a biologically plausible target for adjunctive therapeutic interventions. The aim of the study was to evaluate the clinical evidence on the relationship between gut microbiota composition and major depressive disorder (MDD) and to examine the effects of microbiota-targeted interventions on depressive symptoms. PubMed, Embase, and PsycINFO were searched for clinical studies published through January 2025; observational studies and randomized controlled trials (RCTs) were included, while preclinical studies and case reports were excluded. Ten studies met the predefined eligibility criteria. Patients with MDD showed alterations in microbial composition, differences in diversity, and a reduced relative abundance of short-chain fatty acid (SCFA)-producing bacteria, although findings varied across studies. In some samples, inflammatory markers were associated with symptom severity. Randomized trials of probiotic supplementation showed modest but statistically significant improvements in depressive symptoms. Methodological heterogeneity was substantial. The authors state that the available clinical evidence supports an association between gut microbiota alterations and MDD and highlights the relevance of the microbiome to future individualized treatment strategies in psychiatry. The poster does not report a pooled effect size, ratio, or p-value. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1481) How to cite this study APA 7: Oliveira, I. P., et al. (2026, September 24). Alterations in gut microbiota in major depressive disorder: a systematic review and clinical implications [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1481 Vancouver: Oliveira IP, et al. Alterations in gut microbiota in major depressive disorder: a systematic review and clinical implications [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1481 Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [Dikkat eksikliği hiperaktivite bozukluğu olan beliren yetişkinlerde biriktiricilik belirtileri ve davranışları](https://alisanburak.com/en/wcp-2026-posterler/ev0068) - [Tanı konmamış erişkin dikkat eksikliği/hiperaktivite bozukluğunun anksiyete ve depresif bozukluklar için sürdürücü etken olması: bir literatür derlemesi](https://alisanburak.com/en/wcp-2026-posterler/ev0069) - [DEHB, mükemmeliyetçilik ve öz şefkat: olumsuz duygulanıma giden yollar](https://alisanburak.com/en/wcp-2026-posterler/ev0083) - [Anksiyete ile ilişkili bozukluklarda kendi kendine yönlendirilen sanal gerçeklik terapisinin etkililiği: sistematik derleme ve meta-analiz](https://alisanburak.com/en/wcp-2026-posterler/ev0109) - [Birinci basamakta orta şiddette yaygın anksiyete bozukluğunda bilişsel davranışçı terapinin SSGİ ile karşılaştırılması: kontrollü klinik çalışma](https://alisanburak.com/en/wcp-2026-posterler/ev0110) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/so145 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim