# Polygenic scores for placental efficiency in psychosis spectrum disorders - URL: https://alisanburak.com/en/wcp-2026-posterler/so099 - Language: en - Last updated: not specified - Page title: Polygenic scores for placental efficiency in psychosis spectrum disorders | WCP 2026 Summary > Polygenic scores for placental efficiency were not independently associated with case–control status; a significant interaction was found only between the thir… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so099) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. SO099 Kısa Sözlü Poster SunumuPsikoz ve ŞizofreniOlgu kontrol çalışması (genetik ilişkilendirme) # Polygenic scores for placental efficiency in psychosis spectrum disorders PLACENTAL EFFICIENCY POLYGENIC SCORES IN PSYCHOSIS SPECTRUM DISORDERS Sunan: Jonas Ø. Andersen Ülke: Norway Oturum: 2790 - PARALLEL SHORT ORAL POSTER SESSIONS: PSYCHOSIS & SCHIZOPHRENIA - Part II Tarih: Thu, 24.09.2026 Polygenic scores for placental efficiency were not independently associated with case–control status; a significant interaction was found only between the third principal component and sex (OR = 0.7, p < 0.05). Severe mental disorders such as schizophrenia and bipolar disorder are understood within a neurodevelopmental framework in which early biological processes shape later susceptibility. Placental efficiency (PLE), measured as the ratio of birth weight to placental weight (BW:PW), is a genetically distinct trait that reflects the placenta’s capacity to support fetal development and is linked to pathways that overlap with those implicated in psychiatric disorders; whether genetic predisposition to PLE differs between individuals with psychosis spectrum disorders and healthy controls remains unknown. Based on the researchers’ previous BW:PW GWAS in 63,894 term infants from the MoBa cohort, PLE polygenic scores (ePGS) were calculated using PRSice-2 and applied to 1,317 participants from the TOP study (753 healthy controls, 290 with bipolar disorder, and 274 with schizophrenia); principal component analysis (PCA) was applied to the polygenic risk score profiles. None of the principal components derived from ePGS showed an independent association with case–control status. However, a significant interaction was found between ePGS-PC3 and sex (OR = 0.7, p < 0.05), suggesting that genetic effects related to PLE may be protective against psychosis risk in women. According to the authors, the relationship between PLE genetics and psychosis may operate in a context-dependent manner rather than solely through main genetic effects, and may influence susceptibility in a sex-dependent way. PCA applied to polygenic scores is presented as a useful framework for capturing subtle and moderating genetic effects. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1647) Bu çalışmaya nasıl atıf yapılır? APA 7: Andersen, J. Ø., et al. (2026, September 24). Placental efficiency polygenic scores in psychosis spectrum disorders [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1647 Vancouver: Andersen JØ, et al. Placental efficiency polygenic scores in psychosis spectrum disorders [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1647 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [İlk atak psikoz ve esrar kullanım bozukluğu olan gençlerde yardım arama: Back to Reality video oyun serisinden çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0002) - [Kimyasal bağımlılığın eşlik ettiği tedaviye dirençli şizofreni hastalarında modern antipsikotiklerin kombine kullanımının klinik sonuçları](https://alisanburak.com/en/wcp-2026-posterler/ev0014) - [Şizofrenide bilişsel gerileme: Sosyal işlevsellik üzerindeki etkisi ve bilişsel iyileştirme olanakları](https://alisanburak.com/en/wcp-2026-posterler/ev0018) - [Ağır kişilerarası şiddet öyküsü olan, şizofrenisi olan ve olmayan bireylerde temel benlik bozukluklarının karşılaştırılması](https://alisanburak.com/en/wcp-2026-posterler/ev0103) - [Yoğun çakra odaklı meditasyonla ilişkili bir ergende akut ve geçici psikotik bozukluk: olgu sunumu](https://alisanburak.com/en/wcp-2026-posterler/ev0231) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/so099 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. 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