# Circadian activity rhythms and proteomic pathways mediate the association between depression and Parkinson’s disease: evidence from large-scale cohort analyses - URL: https://alisanburak.com/en/wcp-2026-posterler/so069 - Language: en - Last updated: not specified - Page title: Circadian activity rhythms and proteomic pathways mediate the association between depression and Parkinson’s disease: evidence from large-scale cohort analyses | WCP 2026 Summary > Late-onset depression increases the risk of Parkinson’s disease approximately 2.6-fold, with sleep–activity rhythm measures accounting for the largest mediatio… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so069) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. SO069 Kısa Sözlü Poster SunumuNörobilim ve GörüntülemeKohort # Circadian activity rhythms and proteomic pathways mediate the association between depression and Parkinson’s disease: evidence from large-scale cohort analyses CIRCADIAN–ACTIVITY RHYTHM AND PROTEOMIC PATHWAYS MEDIATE THE ASSOCIATION BETWEEN DEPRESSION AND PARKINSON’S DISEASE: EVIDENCE FROM LARGE-SCALE COHORT ANALYSES Sunan: Guimei Zhang Ülke: China Kurum: The Affiliated Brain Hospital, Guangzhou Medical University, Center for Sleep and Circadian Medicine Oturum: 2760 - PARALLEL SHORT ORAL POSTER SESSIONS: MISCELLANEOUS - Part II Tarih: Thu, 24.09.2026 Late-onset depression increases the risk of Parkinson’s disease approximately 2.6-fold, with sleep–activity rhythm measures accounting for the largest mediation effects in this association. The study aimed to investigate the association between late-onset depression (LOD) and incident Parkinson’s disease (PD), along with the proteomic mechanisms underlying this association. The population-based cohort analysis included 484,590 UK Biobank participants after excluding those with a PD diagnosis preceding LOD, other relevant psychiatric conditions, or missing covariate data; restricted cubic splines and multivariable Cox proportional hazards models were used. In a proteomic subgroup of 52,878 individuals in whom 2,920 plasma proteins were measured, differential expression analysis, principal component analysis (PCA), orthogonal partial least squares discriminant analysis (OPLS-DA), mediation analysis, functional enrichment analysis, and machine learning methods were applied. In addition, a LASSO-Cox risk model was developed in 81,806 participants, including 3,456 with LOD, and validation was performed in 6,352 NHANES participants, 79 of whom had PD. After multivariable adjustment, LOD was significantly associated with incident PD risk (hazard ratio [HR] = 2.59; 95% confidence interval [CI]: 2.12 to 3.16; HR in the basic model = 2.45; 95% CI: 2.01 to 2.99); the association between depressive symptoms and PD was also confirmed in NHANES (adjusted HR = 3.36; 95% CI: 1.62 to 6.97). Proteomic mediation analysis identified 87 potential mediator proteins enriched in cytokine–cytokine receptor interaction, leukocyte transendothelial migration, and cell adhesion pathways; however, sleep–activity rhythm measures accounted for the highest proportions mediated: activity levels during the most active 10-hour period (M10), 15.6%; average daily acceleration, 12.3%; relative amplitude, 7.6%; and the cosinor midline level, 7.6%. The contribution of traditional inflammatory markers was relatively small. Participants classified as high-risk based on the LASSO-Cox score had a higher hazard of PD than those classified as low-risk, both in the overall sample (HR = 6.26; 95% CI: 5.12 to 7.66) and in the LOD subgroup (HR = 5.18; 95% CI: 3.02 to 8.89); the abstract reported that the time-dependent area under the curve (AUC) reached 0.825. The authors emphasize that sleep–activity rhythm characteristics may be modifiable targets, but that interventional studies and independent validation of the risk model are needed before clinical implementation. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/601) Bu çalışmaya nasıl atıf yapılır? APA 7: Zhang, G., et al. (2026, September 24). Circadian–activity rhythm and proteomic pathways mediate the association between depression and parkinson’s disease: evidence from large-scale cohort analyses [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/601 Vancouver: Zhang G, et al. Circadian–activity rhythm and proteomic pathways mediate the association between depression and parkinson’s disease: evidence from large-scale cohort analyses [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/601 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [5-HTTLPR ve MAOA genotiplerinin Iowa kumar görevinde risk altında karar verme üzerindeki farklı duyarlılık etkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0042) - [Duygusal düzensizliği olan erişkin DEHB hastalarında merkezi noradrenalin taşıyıcısı erişilebilirliğinin [11C]MRB PET/MRI ile in vivo görüntülenmesi ve nicelenmesi](https://alisanburak.com/en/wcp-2026-posterler/ev0065) - [Erişkin DEHB'de sapmış beyin kritikliği: uzun erimli zamansal korelasyonlar ve görüntüleme transkriptomiğinden çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0067) - [Anksiyete biyobelirteci olarak fibroblast büyüme faktörü 2: tehdide yönelik dikkat yanlılığıyla ilişkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0120) - [Trajedi paradoksu: hüzünlü müzikle olumlu duygudurum düzenlenmesinin psikolojik ve nörobiyolojik mekanizmaları](https://alisanburak.com/en/wcp-2026-posterler/ev0134) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/so069 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. 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